Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers

Authors

  • Hitosuke Tameno MD,

    1. Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan
    2. Department of Otolaryngology–Head & Neck Surgery, Kyoto Prefectural University of Medicine, Kajiicho, Kamigyo-ku, Kyoto, Japan
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    • The first 2 authors contributed equally to this work.

  • Tokuhiro Chano MD, PhD,

    Corresponding author
    1. Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan
    • Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan
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    • The first 2 authors contributed equally to this work.

  • Kaichiro Ikebuchi MD, PhD,

    1. Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan
    2. Department of Otolaryngology–Head & Neck Surgery, Kyoto Prefectural University of Medicine, Kajiicho, Kamigyo-ku, Kyoto, Japan
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  • Yasuko Ochi MD,

    1. Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan
    2. Department of Otolaryngology–Head & Neck Surgery, Kyoto Prefectural University of Medicine, Kajiicho, Kamigyo-ku, Kyoto, Japan
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  • Akihito Arai MD,

    1. Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan
    2. Department of Otolaryngology–Head & Neck Surgery, Kyoto Prefectural University of Medicine, Kajiicho, Kamigyo-ku, Kyoto, Japan
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  • Mitsuo Kishimoto MD,

    1. Department of Pathology, Kyoto Prefectural University of Medicine, Kajiicho, Kamigyo-ku, Kyoto, Japan
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  • Taketoshi Shimada MD, PhD,

    1. Department of Otolaryngology–Head & Neck Surgery, Kyoto Prefectural University of Medicine, Kajiicho, Kamigyo-ku, Kyoto, Japan
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  • Yasuo Hisa MD, PhD,

    1. Department of Otolaryngology–Head & Neck Surgery, Kyoto Prefectural University of Medicine, Kajiicho, Kamigyo-ku, Kyoto, Japan
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  • Hidetoshi Okabe MD, PhD

    1. Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Japan
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Abstract

Background

No generally agreed-upon method is available for predicting the prognosis of salivary gland cancers. RB1-inducible coiled-coil 1 (RB1CC1) is a positive regulator for the retinoblastoma tumor suppressor (RB1) pathway, and is a suitable marker for evaluating the clinical course of breast cancer. We investigated whether RB1CC1 predicts the prognosis of salivary gland cancers.

Methods

Molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and Ki-67, were evaluated immunohistochemically in 36 cases of salivary gland cancers. The relationships between clinicopathologic features and disease-free-survival intervals were analyzed by a Kaplan–Meier log-rank test and a multivariate Cox proportional hazard regression.

Results

Nuclear RB1CC1 loss in the tumors was significantly associated with a worse disease-free survival (log-rank test, chi-square value = 11.644, p = .0006), and was the maximum critical risk (multivariate Cox proportional hazard ratio = 11.112, 95% confidence interval [CI] = 1.776–69.510, p = .0100).

Conclusions

Nuclear expression of RB1CC1 predicts a better clinical outcome and is useful in the follow-up of salivary gland cancers. © 2011 Wiley Periodicals, Inc. Head Neck, 2012

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