The first 2 authors contributed equally to this work.
Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers
Article first published online: 29 JUN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 5, pages 674–680, May 2012
How to Cite
Tameno, H., Chano, T., Ikebuchi, K., Ochi, Y., Arai, A., Kishimoto, M., Shimada, T., Hisa, Y. and Okabe, H. (2012), Prognostic significance of RB1-inducible coiled-coil 1 in salivary gland cancers. Head Neck, 34: 674–680. doi: 10.1002/hed.21797
- Issue published online: 6 APR 2012
- Article first published online: 29 JUN 2011
- Manuscript Accepted: 3 MAR 2011
- KAKENHI (Grant-in-Aid for Scientific Research on Priority Areas) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Japanese Society of Laboratory Medicine Fund for the Promotion of Scientific Research
- RB1CC1 (RB1-inducible coiled-coil 1);
- RB1 (retinoblastoma tumor suppressor);
- p53 (p53 tumor suppressor);
- salivary gland cancer
No generally agreed-upon method is available for predicting the prognosis of salivary gland cancers. RB1-inducible coiled-coil 1 (RB1CC1) is a positive regulator for the retinoblastoma tumor suppressor (RB1) pathway, and is a suitable marker for evaluating the clinical course of breast cancer. We investigated whether RB1CC1 predicts the prognosis of salivary gland cancers.
Molecules involved in the RB1CC1 pathway, including RB1CC1, RB1, p53, and Ki-67, were evaluated immunohistochemically in 36 cases of salivary gland cancers. The relationships between clinicopathologic features and disease-free-survival intervals were analyzed by a Kaplan–Meier log-rank test and a multivariate Cox proportional hazard regression.
Nuclear RB1CC1 loss in the tumors was significantly associated with a worse disease-free survival (log-rank test, chi-square value = 11.644, p = .0006), and was the maximum critical risk (multivariate Cox proportional hazard ratio = 11.112, 95% confidence interval [CI] = 1.776–69.510, p = .0100).
Nuclear expression of RB1CC1 predicts a better clinical outcome and is useful in the follow-up of salivary gland cancers. © 2011 Wiley Periodicals, Inc. Head Neck, 2012