EGFR expression in advanced head and neck cutaneous squamous cell carcinoma

Authors

  • Larissa Sweeny MD,

    1. Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    Search for more papers by this author
  • Nichole R. Dean DO,

    1. Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    Search for more papers by this author
  • J. Scott Magnuson MD,

    1. Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    Search for more papers by this author
  • William R. Carroll MD,

    1. Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    Search for more papers by this author
  • Emily E. Helman MS,

    1. Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    Search for more papers by this author
  • Stephen O. Hyde BS,

    1. Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    Search for more papers by this author
  • Renee L. Desmond PhD, DVM,

    1. Department of Medicine, Medical Statistics Section, Biostatistics and Bioinformatics Unit, University of Alabama at Birmingham, Birmingham, Alabama
    Search for more papers by this author
  • Eben L. Rosenthal MD

    Corresponding author
    1. Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    • Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama
    Search for more papers by this author

Abstract

Background

The significance of epidermal growth factor receptor (EGFR) expression in advanced cutaneous squamous cell carcinoma (SCC) of the head and neck remains poorly understood.

Methods

We performed a retrospective review of patients with advanced-stage (stage III or stage IV) cutaneous SCC of the head and neck (n = 56).

Results

The majority of patients (91%) had stage III disease, with 54% having regional metastasis and 9% with distant metastasis. Two-year survival was 64% and the 5-year survival was 56%. EGFR was found to be overexpressed in 56% of primary tumors and 58% of regional metastatic disease. Overall survival did not correlate with EGFR (p = .47) expression in primary lesions, nor was it associated with an increase in regional (p = .74) or distant metastasis (p = .56). Furthermore, there was no correlation between clinicopathologic characteristics and EGFR expression

Conclusions

These data do not suggest upregulation of EGFR is associated with poor survival or aggressive disease. © 2011 Wiley Periodicals, Inc. Head Neck, 2012

Ancillary