Identification of a cut-off for the macis score to predict the prognosis of differentiated thyroid carcinoma in children and young adults
Version of Record online: 11 JUL 2011
Copyright © 2011 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 5, pages 696–701, May 2012
How to Cite
Jang, H. W., Lee, J. I., Kim, H. K., Oh, Y. L., Choi, Y., Jin, D., Kim, J., Chung, J. H. and Kim, S. W. (2012), Identification of a cut-off for the macis score to predict the prognosis of differentiated thyroid carcinoma in children and young adults. Head Neck, 34: 696–701. doi: 10.1002/hed.21808
- Issue online: 6 APR 2012
- Version of Record online: 11 JUL 2011
- Manuscript Accepted: 16 MAR 2011
- differentiated thyroid carcinoma;
- young adult;
The metastases, age at diagnosis, completeness of resection, invasion, size of the tumor (MACIS) scoring system was developed to predict disease-specific survival in patients with differentiated thyroid carcinoma (DTC), mainly for adults, with a cut-off score of 6. The purpose of this study was to evaluate its ability to predict prognosis of DTC in children and young adults.
The medical records of 66 children and young adult (<21 years old) patients with DTC were reviewed retrospectively. Receiver operating characteristic (ROC) analysis was performed to determine the cut-off for predicting poor prognosis.
Extrathyroidal invasion and regional lymph node metastasis were noted in 64% each, and distant metastases were found in 8%. The optimal cut-off for the MACIS score for poor prognosis was 4 (93% sensitivity, 67% specificity). The overall 10-year recurrence-free survival was better in patients with MACIS score <4 than score ≥4 (p < .05).
A MACIS score of more than 4 was associated with a poor prognosis in children and young adult patients with DTC. © 2011 Wiley Periodicals, Inc. Head Neck, 2012