This work was presented in abstract form at the Frontiers in Cancer Prevention Research Conference, Philadelphia, Pennsylvania, December 5–8, 2007.
Salivary protein and solCD44 levels as a potential screening tool for early detection of head and neck squamous cell carcinoma†
Article first published online: 11 JUL 2011
Copyright © 2011 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 5, pages 687–695, May 2012
How to Cite
Franzmann, E. J., Reategui, E. P., Pereira, L. H. M., Pedroso, F., Joseph, D., Allen, G. O., Hamilton, K., Reis, I., Duncan, R., Goodwin, W. J., Hu, J. J. and Lokeshwar, V. B. (2012), Salivary protein and solCD44 levels as a potential screening tool for early detection of head and neck squamous cell carcinoma. Head Neck, 34: 687–695. doi: 10.1002/hed.21810
- Issue published online: 6 APR 2012
- Article first published online: 11 JUL 2011
- Manuscript Accepted: 16 MAR 2011
- Flight Attendant Medical Research Institute. Grant Number: 12536
- National Cancer Institute. Grant Number: R03CA107828, R01CA118584
- soluble CD44;
- ELISA assay;
- head and neck squamous cell carcinoma;
- upper aerodigestive tract
Head and neck squamous cell carcinoma (HNSCC) is a devastating disease usually diagnosed at a late stage when cure rates are 40%. We examined a simple and inexpensive molecular tool that may aid HNSCC detection.
Building on prior findings that total protein levels are elevated in 102 HNSCC cases versus 84 control subjects, we further analyzed these levels with respect to important risk and demographic variables and compared the results to soluble CD44 (solCD44). Using multivariate adaptive regression splines (MARSs)-logit modeling and logistic regression, we determined whether total protein, solCD44, or the combination best identifies HNSCC.
Combined higher levels of solCD44 and protein were significantly associated with HNSCC (odds ratio [OR] = 24.90; 95% confidence interval [CI], 9.04–68.57; area under the curve [AUC] = 0.786). A model including protein plus solCD44 resulted in a better area (AUC 0.796) than either marker alone.
Oral rinse levels of solCD44 and protein seem to hold promise for detection of HNSCC. © 2011 Wiley Periodicals, Inc. Head Neck, 2012