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Salivary protein and solCD44 levels as a potential screening tool for early detection of head and neck squamous cell carcinoma

Authors

  • Elizabeth J. Franzmann MD,

    Corresponding author
    1. Sylvester Comprehensive Cancer Center/University of Miami Leonard Miller School of Medicine, Miami, Florida
    2. Department of Otolaryngology, University of Miami Leonard Miller School of Medicine, Miami, Florida
    • Sylvester Comprehensive Cancer Center/University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • Erika P. Reategui MS,

    1. Department of Clinical Research Administration, University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • Lutecia H. Mateus Pereira PhD,

    1. Sylvester Comprehensive Cancer Center/University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • Felipe Pedroso MD,

    1. Department of Pediatrics, New York Presbyterian–Weill Cornell Medical College, New York, New York
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  • Debbie Joseph MD,

    1. Department of Otolaryngology, University of Florida, Gainesville, Florida
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  • Glenn O. Allen MPH,

    1. Sylvester Comprehensive Cancer Center/University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • Kara Hamilton MPH,

    1. Institute for Human Genomics, University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • Isildinha Reis DrPH,

    1. Department of Epidemiology and Public Health, University of Miami Leonard Miller School of Medicine, Miami, Florida
    2. Sylvester Comprehensive Cancer Center, Division of Biostatistics, University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • Robert Duncan PhD,

    1. Department of Epidemiology and Public Health, University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • W. Jarrard Goodwin MD,

    1. Sylvester Comprehensive Cancer Center/University of Miami Leonard Miller School of Medicine, Miami, Florida
    2. Department of Otolaryngology, University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • Jennifer J. Hu PhD,

    1. Sylvester Comprehensive Cancer Center/University of Miami Leonard Miller School of Medicine, Miami, Florida
    2. Department of Epidemiology and Public Health, University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • Vinata B. Lokeshwar PhD

    1. Sylvester Comprehensive Cancer Center/University of Miami Leonard Miller School of Medicine, Miami, Florida
    2. Department of Urology, University of Miami Leonard Miller School of Medicine, Miami, Florida
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  • This work was presented in abstract form at the Frontiers in Cancer Prevention Research Conference, Philadelphia, Pennsylvania, December 5–8, 2007.

Abstract

Background

Head and neck squamous cell carcinoma (HNSCC) is a devastating disease usually diagnosed at a late stage when cure rates are 40%. We examined a simple and inexpensive molecular tool that may aid HNSCC detection.

Methods

Building on prior findings that total protein levels are elevated in 102 HNSCC cases versus 84 control subjects, we further analyzed these levels with respect to important risk and demographic variables and compared the results to soluble CD44 (solCD44). Using multivariate adaptive regression splines (MARSs)-logit modeling and logistic regression, we determined whether total protein, solCD44, or the combination best identifies HNSCC.

Results

Combined higher levels of solCD44 and protein were significantly associated with HNSCC (odds ratio [OR] = 24.90; 95% confidence interval [CI], 9.04–68.57; area under the curve [AUC] = 0.786). A model including protein plus solCD44 resulted in a better area (AUC 0.796) than either marker alone.

Conclusion

Oral rinse levels of solCD44 and protein seem to hold promise for detection of HNSCC. © 2011 Wiley Periodicals, Inc. Head Neck, 2012

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