Implications of a positive sentinel node in oral squamous cell carcinoma
Article first published online: 31 JAN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 11, pages 1580–1585, November 2012
How to Cite
Gurney, B. A. S., Schilling, C., Putcha, V., Alkureishi, L. W., Alvarez, A. J., Bakholdt, V., Barbier Herrero, L., Barzan, L., Bilde, A., Bloemena, E., Salces, C. C., Palma, P. D., de Bree, R., Dequanter, D., Dolivet, G., Donner, D., Flach, G. B., Fresno, M., Grandi, C., Haerle, S., Huber, G. F., Hunter, K., Lawson, G., Leroux, A., Lothaire, P. H., Mamelle, G., Silini, E. M., Mastronicola, R., Odell, E. W., O'Doherty, M. J., Poli, T., Rahimi, S., Ross, G. L., Zuazua, J. S., Santini, S., Sebbesen, L., Shoaib, T., Sloan, P., Sorensen, J. A., Soutar, D. S., Therkildsen, M. H., Vigili, M. G., Villarreal, P. M., von Buchwald, C., Werner, J. A., Wiegand, S. and McGurk, M. (2012), Implications of a positive sentinel node in oral squamous cell carcinoma. Head Neck, 34: 1580–1585. doi: 10.1002/hed.21973
- Issue published online: 20 OCT 2012
- Article first published online: 31 JAN 2012
- Manuscript Accepted: 7 SEP 2011
- Manuscript Revised: 29 AUG 2011
- Manuscript Received: 30 DEC 2009
- sentinel node biopsy;
- oral cancer;
- squamous cell cancer;
- head and neck;
The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.
In all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan–Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.
A total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.
The results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans. © 2012 Wiley Periodicals, Inc. Head Neck, 2012