This work was presented at the American Head and Neck Society Research Workshop, Arlington, Virginia, October 2010.
Matted nodes: Poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status†
Article first published online: 13 JAN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Head & Neck
Volume 34, Issue 12, pages 1727–1733, December 2012
How to Cite
Spector, M. E., Gallagher, K. K., Light, E., Ibrahim, M., Chanowski, E. J., Moyer, J. S., Prince, M. E., Wolf, G. T., Bradford, C. R., Cordell, K., McHugh, J. B., Carey, T., Worden, F. P., Eisbruch, A., Chepeha, D. B. and The University of Michigan Head Neck Specialized Program of Research Excellence (SPORE) Program (2012), Matted nodes: Poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status. Head Neck, 34: 1727–1733. doi: 10.1002/hed.21997
- Issue published online: 17 NOV 2012
- Article first published online: 13 JAN 2012
- Manuscript Accepted: 13 SEP 2011
- P50 CA97248 National Institutes of Health (NIH) National Cancer Institute (NCI) NIDCR Specialized Program of Research Excellence (SPORE), SPORE in Head and Neck Cancer – The Molecular Basis of Head and Neck Cancer Therapy, PI: Gregory Wolf, MD
- oropharyngeal squamous cell carcinoma;
- matted nodes;
- lymph node metastasis
Despite better prognosis, there is a group of oropharyngeal squamous cell carcinoma (SCC) human papillomavirus (HPV)+ patients who experience treatment failure and succumb to distant metastasis.
Seventy-eight previously untreated patients nested in a concurrent chemoradiation protocol were reviewed to correlate patterns of local-regional tumor extent to distant metastasis. Biomarker assessment was: HPV in situ hybridization and epidermal growth factor receptor (EGFR) immunointensity.
The 3-year disease-specific survival (DSS) for patients presenting with and without matted nodes was 69% and 94%, respectively (p = .003). Matted nodes were a poor prognostic factor independent of T classification, HPV, EGFR, and smoking status. For patients who were HPV+, 7 of 11 died of distant metastasis and 6 of 7 with distant metastasis had matted nodes.
Matted nodes are a novel marker of poor prognosis in oropharyngeal SCC independent of established prognostic factors. Matted nodes may identify patients at risk for the development of distant metastasis who could benefit from systemic therapy, whereas patients without matted nodes may be candidates for de-escalation of therapy. © 2012 Wiley Periodicals, Inc. Head Neck, 2012