Stage grouping in tumors of the ethmoid sinuses and the nasal cavity using the sixth edition of the UICC classification of malignant tumors

Authors

  • Matthias Kreppel MD, DMD,

    Corresponding author
    1. Department of Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, 50931 Cologne, Germany
    2. Center of Integrated Oncology (CIO), Cologne-Bonn, Germany
    • Department of Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Kerpener Strasse 62, 50931 Cologne, Germany
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  • Martin Scheer MD, DMD,

    1. Department of Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, 50931 Cologne, Germany
    2. Center of Integrated Oncology (CIO), Cologne-Bonn, Germany
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  • Dirk Beutner MD,

    1. Center of Integrated Oncology (CIO), Cologne-Bonn, Germany
    2. Department of Oto-Rhino-Laryngology and Head Neck Surgery, University of Cologne, 50931 Cologne, Germany
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  • Uta Drebber MD, PhD,

    1. Center of Integrated Oncology (CIO), Cologne-Bonn, Germany
    2. Department of Pathology, University of Cologne, 50931 Cologne, Germany
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  • Robert Semrau MD,

    1. Center of Integrated Oncology (CIO), Cologne-Bonn, Germany
    2. Department of Radiation Oncology, University of Cologne, 50931 Cologne, Germany
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  • Joachim E. Zöller MD, DMD, PhD,

    1. Department of Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, 50931 Cologne, Germany
    2. Center of Integrated Oncology (CIO), Cologne-Bonn, Germany
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  • Orlando Guntinas–Lichius MD, PhD

    1. Department of Oto-Rhino-Laryngology and Head Neck Surgery, Friedrich Schiller University of Jena, Jena, Germany
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  • Conflict of interest: none.

Abstract

Background

The purpose of this study was to evaluate the prognostic impact of the sixth edition of the Union Internationale Contre le Cancer (UICC) classification and different TNM-based stage groupings for malignant tumors of the ethmoid sinuses and the nasal cavity.

Methods

We conducted a retrospective analysis of 98 patients with malignant tumors of the ethmoid sinuses and the nasal cavity between 1967 and 2003. The UICC classification of the sixth edition and the T and N Integer Score (TANIS) and Hart were tested for their prognostic significance.

Results

In univariate analysis, all stage groupings revealed discriminatory power for overall survival (OS; p < .05), however, in multivariate analysis only the UICC-stage grouping (p = .033) and the TANIS-8 scheme (p = .044) predicted OS. The TANIS did not have a better prognostic quality than the sixth edition of the UICC classification.

Conclusion

The UICC-stage grouping of the sixth edition is a good prognostic index for malignant tumors of the ethmoid sinuses and the nasal cavity. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

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