Morphogenesis of the human laryngeal ventricles

Authors

  • Fermín Viejo MD, PhD,

    1. Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
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  • Arán Pascual-Font PhD,

    1. Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
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  • Luis Rivas MD, PhD,

    1. Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
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  • Ignacio Hernández-Morato BsC,

    1. Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
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  • Teresa Vázquez PhD,

    1. Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
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  • Marc Rodriguez-Niedenführ MD, PhD,

    1. Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
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  • Stephen McHanwell PhD,

    1. Oral Biology, School of Dental Sciences, Dental School, Framlington Place, Newcastle upon Tyne, United Kingdom
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  • José R. Sanudo MD, PhD

    Corresponding author
    1. Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Spain
    • Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Ciudad Universitaria s/n, Universidad Complutense de Madrid, 28040-Madrid, Spain
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Abstract

Background

Two theories explain the origin of human laryngeal ventricles: (1) ventricles derive from the fifth pharyngeal pouches; (2) development independent from the pouches.

Methods

In all, there were 21 serially sectioned human embryos from stages 15 to 23, and 11 fetuses of 9 to 18 weeks. Computer-aided 3-dimentional reconstructions were made.

Results

The cranial part of the laryngeal sulcus and future vestibule expands from the pharyngeal floor between the third and fourth pharyngeal pouches during stages 15 and 16 (33–37 days). The primordia of the ventricles appeared at stage 18 (44 days) as 2 lateral swellings in the caudal end of the future vestibule, limited by the third pharyngeal pouches. Active epithelial expansion and subsequent canalization during late embryonic and early fetal periods finalizes their development.

Conclusions

The laryngeal ventricles do not derive from the pharyngeal pouches but the median region of the pharyngeal floor between the third and fourth pharyngeal pouches and arches at the caudal end of the future vestibule. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

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