Outcomes of squamous cell cancer of the oral tongue managed at the princess margaret hospital
Article first published online: 27 APR 2012
Copyright © 2012 Wiley Periodicals, Inc.
Head & Neck
Volume 35, Issue 5, pages 632–641, May 2013
How to Cite
Goldstein, D. P., Bachar, G. Y., Lea, J., Shrime, M. G., Patel, R. S., Gullane, P. J., Brown, D. H., Gilbert, R. W., Kim, J., Waldron, J., Perez–Ordonez, B., Davis, A. M., Cheng, L., Xu, W. and Irish, J. C. (2013), Outcomes of squamous cell cancer of the oral tongue managed at the princess margaret hospital. Head Neck, 35: 632–641. doi: 10.1002/hed.23001
- Issue published online: 6 APR 2013
- Article first published online: 27 APR 2012
- Manuscript Accepted: 3 FEB 2012
- tongue cancer;
- squamous cell carcinoma;
- oral cancer;
- treatment outcome;
The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival.
We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. Kaplan–Meier estimates, log-rank test, and Cox regression models were used for statistical analysis.
Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification.
Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival. © 2012 Wiley Periodicals, Inc. Head Neck, 2013