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Keywords:

  • oral cancer;
  • maté consumption;
  • confounding;
  • interaction;
  • benzo[a]pyrene

Abstract

Background

In the period 1990 to 2001, a case-control study on oral cancer and maté consumption was conducted at the Cancer Institute of Uruguay.

Methods

The study included 696 newly diagnosed cases with squamous cell carcinoma and 696 controls afflicted with nonneoplastic conditions not related to tobacco smoking and alcohol drinking. The participants were matched on age and residence and the study was restricted to men.

Results

In order to control confounding for tobacco and alcohol, we fitted 2 models. According to model 1, the odds ratio (OR) for maté consumption was 1.15 (95% confidence interval [CI], 0.76–1.73), whereas the results for model 2 showed an OR of 3.47 (95% CI, 1.60–7.52).

Conclusions

The inclusion of a term for the interaction between maté and smoking (or drinking) was rewarding and the ORs were even higher than those observed with the crude estimates. Head Neck, 2013