The first two authors contributed equally to this work.
Basic Science Review
Lessons learned from next-generation sequencing in head and neck cancer†
Version of Record online: 21 AUG 2012
Copyright © 2012 Wiley Periodicals, Inc.
Head & Neck
Volume 35, Issue 3, pages 454–463, March 2013
How to Cite
Loyo, M., Li, R. J., Bettegowda, C., Pickering, C. R., Frederick, M. J., Myers, J. N., Agrawal, N. (2013), Lessons learned from next-generation sequencing in head and neck cancer. Head Neck, 35: 454–463. doi: 10.1002/hed.23100
Myriam Loyo and Ryan J. Li contributed equally to this work.
- Issue online: 16 FEB 2013
- Version of Record online: 21 AUG 2012
- Manuscript Accepted: 25 MAY 2012
- next generation sequencing;
- tumor suppressor gene;
- head and neck squamous cell carcinoma
Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next-generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1, a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: TP53, NOTCH1, HRAS, PIK3CA, and CDKN2A. Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed. © 2012 Wiley Periodicals, Inc. Head Neck, 2013