Risk of developing sudden sensorineural hearing loss in patients with nasopharyngeal carcinoma: A population-based cohort study

Authors

  • Charlene Lin BA,

    1. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California
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  • Shih-Wei Lin BPharm,

    1. Faculty of Pharmaceutical Sciences, University of British Columbia, British Columbia, Canada
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  • Shih-Feng Weng PhD,

    1. Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
    2. Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan
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  • Yung-Song Lin MD

    Corresponding author
    1. Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan
    2. Department of Otolaryngology, Chi Mei Medical Center, Tainan, Taiwan
    • Department of Otolaryngology, School of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei City, 110 Taiwan. E-mail: kingear@gmail.com

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Abstract

Background

The purpose of this study was to explore the risk of developing of sudden sensorineural hearing loss (SSHL) in patients with nasopharyngeal carcinoma (NPC).

Methods

A population-based, retrospective cohort study using the Taiwan National Health Insurance Research Database was conducted. From 2001 to 2006, 9121 patients with newly diagnosed NPC and 45,605 comparison subjects without NPC were selected. The incidence of SSHL at the end of 2009 was determined.

Results

The incidence of SSHL was 6.53-fold higher in the NPC group compared to the non-NPC group (p < .001). Using Cox proportional hazard regressions, the risk of developing SSHL increased with an adjusted hazard ratio (HR) of 6.747 (95% confidence interval [CI] = 5.366–8.484) in patients with NPC compared with patients without NPC.

Conclusion

NPC was significantly associated with an increased risk of developing SSHL. The risk of developing SSHL increased over follow-up time. © 2013 Wiley Periodicals, Inc. Head Neck 36: 203–208, 2014

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