Get access

Basaloid squamous cell carcinoma of the larynx: Analysis of 145 cases with comparison to conventional squamous cell carcinoma

Authors

  • Valerie A. Fritsch MD,

    1. Department of Otolaryngology – Head and Neck Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina
    Search for more papers by this author
  • Eric J. Lentsch MD

    Corresponding author
    1. Department of Otolaryngology – Head and Neck Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina
    • Department of Otolaryngology – Head and Neck Surgery, Hollings Cancer Center, Medical University of South Carolina, 135 Rutledge Avenue MSC 550, Charleston, SC 29425-5500. E-mail: Elentsch@musc.edu

    Search for more papers by this author

Abstract

Background

Basaloid squamous cell carcinoma (BSCC) is a rare subtype squamous cell carcinoma (SCC) that frequently occurs in the larynx. BSCC is generally considered an aggressive SCC variant; however, because of its rarity, most studies are underpowered to detect statistical differences in disease-specific survival (DSS).

Methods

Using the Surveillance, Epidemiology, and End Results (SEER) database, we compared clinicopathologic data and DSS between patients with laryngeal BSCC and SCC.

Results

Patients with relative SCC, those with laryngeal BSCC, presented with more advanced local, regional, and distant disease (p < .001). Patients with BSCC had worse DSS, regardless of stage, tumor location within the larynx (glottis/supraglottis; p < .001), or treatment received (p ≤ .052).

Conclusion

Analysis of the largest laryngeal BSCC series to date (n = 145) demonstrates that BSCC carries a worse prognosis than conventional SCC of the larynx. © 2013 Wiley Periodicals, Inc. Head Neck 36: 164–170, 2014

Ancillary