The investigation involved human subjects and informed consent was obtained from every subject recruited in the study.
Multivariate analysis of prognostic factors for salvage nasopharyngectomy via the maxillary swing approach
Version of Record online: 15 APR 2014
Copyright © 2014 Wiley Periodicals, Inc.
Head & Neck
Volume 36, Issue 7, pages 1013–1017, July 2014
How to Cite
Chan, J. Y. W., To, V. S. H., Chow, V. L. Y., Wong, S. T. S. and Wei, W. I. (2014), Multivariate analysis of prognostic factors for salvage nasopharyngectomy via the maxillary swing approach. Head Neck, 36: 1013–1017. doi: 10.1002/hed.23403
- Issue online: 16 JUN 2014
- Version of Record online: 15 APR 2014
- Accepted manuscript online: 19 JUN 2013 02:35AM EST
- Manuscript Accepted: 4 JUN 2013
- Manuscript Revised: 27 MAR 2013
- Manuscript Received: 9 NOV 2012
- Hong Kong University Grants Committee Area of Excellence (AoE) scheme
- recurrent nasopharyngeal carcinoma;
- prognostic factors;
- maxillary swing nasopharyngectomy;
- multivariate analysis;
- salvage surgery
The purpose of this study was to investigate the prognostic factors for salvage nasopharyngectomy.
A retrospective review was conducted on maxillary swing nasopharyngectomy performed between 1998 and 2010. Univariate and multivariate analyses identified prognostic factors affecting actuarial local tumor control and overall survival.
The median follow-up duration was 52 months. Among the 268 patients, 79.1% had clear resection margins. The 5-year actuarial local tumor control and overall survival was 74% and 62.1%, respectively. On multivariate analysis, tumor size, resection margin status, and gross tumor in the sphenoid sinus were independent prognostic factors for local tumor control. For overall survival, resection margin status, synchronous cervical nodal recurrence, and cavernous sinus invasion had a negative influence on overall survival after surgery.
Extent of nasopharyngectomy should be tailored to the individual tumor to achieve clear resection margins. Cavernous sinus invasion is associated with poor survival outcome, and detailed counseling and meticulous surgical planning is crucial in such circumstances. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1013–1017, 2014