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Transoral laser microsurgery for laryngeal carcinoma: Survival analysis in a hospital-based population

Authors

  • Eduardo Breda MD, PhD,

    Corresponding author
    1. Department of Otolaryngology, Portuguese Institute of Oncology Dr Francisco Gentil, Porto, Portugal
    • Corresponding author: E. Breda, Department of Otolaryngology, Instituto Português de Oncologia do Porto, R António Bernardino de Almeida, 4200-072 Porto, Portugal. E-mail: erbreda@gmail.com

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  • Raquel Catarino MD, PhD,

    1. Department of Molecular Oncology GRP CI, Portuguese Institute of Oncology Dr Francisco Gentil, Porto, Portugal
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  • Eurico Monteiro MD, PhD

    1. Department of Otolaryngology, Portuguese Institute of Oncology Dr Francisco Gentil, Porto, Portugal
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Abstract

Background

Although already established for treatment for early-stage laryngeal cancers, transoral laser microsurgery indications for more advanced tumors are not unanimous. Additionally, no outcomes concerning the Portuguese population are currently accessible.

Methods

Outcomes of 248 patients presenting laryngeal carcinoma primarily treated by transoral laser microsurgery with curative intention in tertiary referral center were retrospectively evaluated and compared with concerning literature.

Results

For supraglottic tumors (23 stage I–II and 20 stage III–IV), 5-year disease-specific survival (DSS) was, respectively, 88.4% and 72.7%, and the total larynx-preservation rate was 90.7%. For glottic cancer (165 stage I–II and 40 stage III–IV), 5-year DSS was, respectively, 96.5% and 90.8% and the larynx preservation rate was 88.3%.

Conclusion

Transoral laser microsurgery, alone or with neck dissection and adjuvant therapy, is an efficient procedure for treatment of laryngeal cancer in different stages. To the best of our knowledge, this is the first study reporting transoral laser microsurgery outcomes in the Portuguese population. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1181–1186, 2015

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