Results of this study were presented at the annual meeting of the American Society for the Study of Liver Disease, Chicago, Illinois, November 1980, and have appeared in abstract form (1).
Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis†
Article first published online: 1 MAR 2006
Copyright © 1981 American Association for the Study of Liver Diseases
Volume 1, Issue 5, pages 431–435, September/October 1981
How to Cite
Knodell, R. G., Ishak, K. G., Black, W. C., Chen, T. S., Craig, R., Kaplowitz, N., Kiernan, T. W. and Wollman, J. (1981), Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology, 1: 431–435. doi: 10.1002/hep.1840010511
- Issue published online: 1 MAR 2006
- Article first published online: 1 MAR 2006
- Manuscript Accepted: 17 JUN 1981
- Manuscript Received: 23 JAN 1981
- The Veterans Administration Cooperative Studies Program
A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis. Biopsies are graded in four categories: periportal necrosis, intralobular necrosis, portal inflammation, and fibrosis. Under code, three pathologists and three hepatologists evaluated 14 liver biopsy specimens obtained from five patients with asymptomatic chronic active hepatitis. Good correlation was seen between severity of liver biopsy lesions as judged by conventional histological descriptions and Histology Activity Index scores. Significant differences in Histology Activity Index score occurred in only 2 of 28 duplicate scorings of biopsy specimens by two observers. This system provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions in following the natural history and treatment responses of asymptomatic chronic active hepatitis.