Delayed HBsAg clearance in chronic hepatitis B viral infection

Authors

  • Karen L. Lindsay,

    Corresponding author
    1. Liver Unit, Departments of Medicine and Pathology, University of Southern California School of Medicine, Rancho Los Amigos Hospital, Downey, California 90242
    • Liver Unit, Building 1100, Room 53, Rancho Los Amigos Hospital, 7601 E. Imperial Highway, Downey, California 90242
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  • Allan G. Redeker,

    1. Liver Unit, Departments of Medicine and Pathology, University of Southern California School of Medicine, Rancho Los Amigos Hospital, Downey, California 90242
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  • Mary Ashcavai

    1. Liver Unit, Departments of Medicine and Pathology, University of Southern California School of Medicine, Rancho Los Amigos Hospital, Downey, California 90242
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Abstract

Seven patients are described in whom HBsAg persisted for 13 to 98 months after acute viral hepatitis B and then became nondetectable. All patients subsequently developed anti-HBs. During the period of HBs-antigenemia, liver biopsies in five patients showed persistent viral hepatitis. Retrospectively, impending negativity of HBsAg was predictable in five patients by a decrease in HBsAg titer, and in four patients by persistent normalization of serum alanine aminotransferase. Although delayed clearance of HBsAg in patients with chronic hepatitis B virus infection is uncommon, it appears to be predictable.

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