The Effect of Portal Diversion on the Early Stages of Liver Carcinogenesis in the Rat

Authors

  • Lorne E. Rotstein,

    1. Departments of Surgery, Pathology, and Biochemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L5
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    • Drs. Rotstein and Makowka were Research Fellows of the Medical Research Council of Canada.

  • Leonard Makowka,

    1. Departments of Surgery, Pathology, and Biochemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L5
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    • Drs. Rotstein and Makowka were Research Fellows of the Medical Research Council of Canada.

  • George Lee,

    1. Departments of Surgery, Pathology, and Biochemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L5
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  • Emmanuel Farber

    Corresponding author
    1. Departments of Surgery, Pathology, and Biochemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L5
    • Emmanuel Farber, M.D., Department of Pathology, University of Toronto, Banting Institute, 100 College Street, Toronto, Ontario, Canada M5G 1L5.
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Abstract

The effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules. These results suggest that vascular factors are not important at these early stages of the carcinogenic process in the rat liver.

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