Drs. Rotstein and Makowka were Research Fellows of the Medical Research Council of Canada.
The Effect of Portal Diversion on the Early Stages of Liver Carcinogenesis in the Rat
Article first published online: 21 SEP 2007
Copyright © 1982 American Association for the Study of Liver Diseases
Volume 2, Issue 1, pages 67S–71S, January/February 1982
How to Cite
Rotstein, L. E., Makowka, L., Lee, G. and Farber, E. (1982), The Effect of Portal Diversion on the Early Stages of Liver Carcinogenesis in the Rat. Hepatology, 2: 67S–71S. doi: 10.1002/hep.1840020111
- Issue published online: 21 SEP 2007
- Article first published online: 21 SEP 2007
- Manuscript Accepted: 30 OCT 1981
- Manuscript Received: 18 AUG 1981
- National Cancer Institute of Canada
- Medical Research Council of Canada
The effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules. These results suggest that vascular factors are not important at these early stages of the carcinogenic process in the rat liver.