Chronic Persistent Hepatitis: Serological Classification and Meaning of the Hepatitis B e System

Authors

  • Jan Aldershvile,

    Corresponding author
    1. Division of Hepatology and Department of Pathology, Hvidovre Hospital, University of Copenhagen; Second Department of Medicine, Kommunehospitalet; Department of Infectious Diseases M, Rigshospitalet, University of Copenhagen; and Department of Enterovirus, Statens Seruminstitut, Copenhagen, Denmark
    • Jan Aldershvile, M.D., Division of Hepatology 233, University of Cophenhagen, DK-2650 Hvidovre Hospital, Denmark.
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  • Odd Dietrichson,

    1. Division of Hepatology and Department of Pathology, Hvidovre Hospital, University of Copenhagen; Second Department of Medicine, Kommunehospitalet; Department of Infectious Diseases M, Rigshospitalet, University of Copenhagen; and Department of Enterovirus, Statens Seruminstitut, Copenhagen, Denmark
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  • Peter SkinhøJ,

    1. Division of Hepatology and Department of Pathology, Hvidovre Hospital, University of Copenhagen; Second Department of Medicine, Kommunehospitalet; Department of Infectious Diseases M, Rigshospitalet, University of Copenhagen; and Department of Enterovirus, Statens Seruminstitut, Copenhagen, Denmark
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  • Peter Kryger,

    1. Division of Hepatology and Department of Pathology, Hvidovre Hospital, University of Copenhagen; Second Department of Medicine, Kommunehospitalet; Department of Infectious Diseases M, Rigshospitalet, University of Copenhagen; and Department of Enterovirus, Statens Seruminstitut, Copenhagen, Denmark
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  • Lars R. Mathiesen,

    1. Division of Hepatology and Department of Pathology, Hvidovre Hospital, University of Copenhagen; Second Department of Medicine, Kommunehospitalet; Department of Infectious Diseases M, Rigshospitalet, University of Copenhagen; and Department of Enterovirus, Statens Seruminstitut, Copenhagen, Denmark
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  • Per Christoffersen,

    1. Division of Hepatology and Department of Pathology, Hvidovre Hospital, University of Copenhagen; Second Department of Medicine, Kommunehospitalet; Department of Infectious Diseases M, Rigshospitalet, University of Copenhagen; and Department of Enterovirus, Statens Seruminstitut, Copenhagen, Denmark
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  • Jens O. Nielsen

    1. Division of Hepatology and Department of Pathology, Hvidovre Hospital, University of Copenhagen; Second Department of Medicine, Kommunehospitalet; Department of Infectious Diseases M, Rigshospitalet, University of Copenhagen; and Department of Enterovirus, Statens Seruminstitut, Copenhagen, Denmark
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  • Other members of the group are: K. Bentsen, V. Faber, C. Gluud, F. Hardt, G. H0ybye, K. Iversen, E. Juhl, M. Orholm, P. Petersen, H. Poulsen, P. Schlichting, T. I. A. Sørensen, and U. Tage-Jensen.

Abstract

In order to evaluate the prognostic implications of the hepatitis B e system in patients with chronic persistent hepatitis (CPH), 53 consecutive patients were studied. Fourteen of 16 patients with HBsAg and HBeAg were followed from 12 to 120 months (mean, 38 months). Eleven of the 14 patients were persistently HBeAg positive and five of these developed chronic active hepatitis (CAH) or cirrhosis. A further nine patients were HBsAg positive but HBeAg negative at time of CPH diagnosis (mean follow-up, 47 months). One of these nine patients developed CAH during follow-up. The remaining 28 patients were all HBsAg negative, and only 2 of the 28 patients progressed to CAH or cirrhosis during the time of follow-up (mean, 43 months). It is concluded that the persistence of HBeAg in patients with CPH indicates a serious prognosis with a frequent transition to CAH or cirrhosis.

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