The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
Hepatocellular Carcinoma in Women: Probable Lack of Etiologic Association with Oral Contraceptive Steroids†
Article first published online: 8 OCT 2007
Copyright © 1982 American Association for the Study of Liver Diseases
Volume 2, Issue 4, pages 440S–444S, July/August 1982
How to Cite
Goodman, Z. D. and Ishak, K. G. (1982), Hepatocellular Carcinoma in Women: Probable Lack of Etiologic Association with Oral Contraceptive Steroids. Hepatology, 2: 440S–444S. doi: 10.1002/hep.1840020408
- Issue published online: 8 OCT 2007
- Article first published online: 8 OCT 2007
- Manuscript Accepted: 2 MAR 1982
- Manuscript Received: 1 DEC 1981
To investigate the possibility of an association between oral contraceptive steroids (CS) and hepatocellular carcinoma (HCC), we reviewed 128 cases of HCC in women collected between 1953 and 1980. There were 48 cases under the age of 40, and 13 of these (27%) had used CS. However, 62% of HCC associated with CS and 58% of HCC in women under 40 not using CS were classified histologically as “fibrolamellar” carcinoma. This subtype of HCC occurs predominantly in young people, both male and female. The apparent increase in HCC in young women can be explained by the presence of cases of fibrolamellar carcinoma in this age group, and the apparent association with CS is probably coincidental.