Geographic Distribution of HBsAg Carriers in China

Authors

  • R. Palmer BEASLEY,

    Corresponding author
    1. University of Washington Medical Research Unit, Institute of Public Health of the College of Medicine of National Taiwan University, Government Employees Center Clinic, Taipei, Taiwan, Republic of China and the U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Manila, Philippines
    • R. Palmer Beasley, M.D., University of Washington Medical Research Unit, 15-2 Kung Yuan Road, Taipei, Taiwan, Republic of China.
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  • Chia-Chin Lin,

    1. University of Washington Medical Research Unit, Institute of Public Health of the College of Medicine of National Taiwan University, Government Employees Center Clinic, Taipei, Taiwan, Republic of China and the U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Manila, Philippines
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  • Chia-Siang Chien,

    1. University of Washington Medical Research Unit, Institute of Public Health of the College of Medicine of National Taiwan University, Government Employees Center Clinic, Taipei, Taiwan, Republic of China and the U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Manila, Philippines
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  • Chien-Jen Chen,

    1. University of Washington Medical Research Unit, Institute of Public Health of the College of Medicine of National Taiwan University, Government Employees Center Clinic, Taipei, Taiwan, Republic of China and the U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Manila, Philippines
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  • Lu-Yu Hwang

    1. University of Washington Medical Research Unit, Institute of Public Health of the College of Medicine of National Taiwan University, Government Employees Center Clinic, Taipei, Taiwan, Republic of China and the U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Manila, Philippines
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Abstract

We tested by radioimmunoassay the sera of 22,707 male Chinese government employees in Taiwan for HBsAg and found 15.2% to be positive. Almost all were confirmed as carriers by follow-up testing 1 year later. This paper presents HBsAg positivity rates of these men according to the province of China from which they originated, and compares the rates with published provincial mortality rates for primary hepatocellular carcinoma. Moderate variation in carrier rates between provinces was observed with high prevalence in men from provinces south of the Yangtze River. There was positive correlation between HBsAg prevalence and primary hepatocellular carcinoma incidence giving further support to the possibility of a causal relationship.

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