Dr. Thomas is supported by the Wellcome Trust and is a Senior Wellcome Fellow in clinical sciences.
Hepatitis B Virus and HLA Antigen Display in the Liver During Chronic Hepatitis B Virus Infection
Article first published online: 21 SEP 2007
Copyright © 1982 American Association for the Study of Liver Diseases
Volume 2, Issue 5, pages 557S–561S, September/October 1982
How to Cite
Montan̄to, L., Miescher, G. C., Goodall, A. H., Wiedmann, K. H., Janossy, G. and Thomas, H. C. (1982), Hepatitis B Virus and HLA Antigen Display in the Liver During Chronic Hepatitis B Virus Infection. Hepatology, 2: 557S–561S. doi: 10.1002/hep.1840020508
- Issue published online: 21 SEP 2007
- Article first published online: 21 SEP 2007
- Manuscript Accepted: 13 APR 1982
- Manuscript Received: 19 JUN 1981
- C.O.N.A.C.Y.T. (Mexico)
- Deutsche Forschungsgemein-schaft
- Bonn, West Germany
An analysis of the expression of the histocompatibility antigens in the livers of patients with chronic hepatitis B virus infection and normal subjects has demonstrated an increased expression of HLA-A,B,C antigens on the hepatocytes of patients with a low level of viral replication (HBe antibody positive) as compared with patients who exhibit a high level of viral replication (HBe antigen positive) and controls. This increase in the expression of histocompatibility antigens on the hepatocytes was associated with a decrease in the membrane expression of viral antigens by the same cells. These differences in the density of HLA and viral antigen display may influence the efficiency of T-cell cytolysis of hepatitis B virus-infected hepatocytes.