Dr. Mirouze is a Clinical Research Fellow in Hepatology.
Article first published online: 21 SEP 2007
Copyright © 1983 American Association for the Study of Liver Diseases
Volume 3, Issue 1, pages 50–55, 1983
How to Cite
Mirouze, D., Zipser, R. D. and Reynolds, T. B. (1983), Effect of Inhibitors of Prostaglandin Synthesis On Induced Diuresis in Cirrhosis. Hepatology, 3: 50–55. doi: 10.1002/hep.1840030108
This work was presented at the meeting of the American Association for the Study of Liver Diseases, Chicago, Illinois, November 8, 1979 and published in abstract form (Gastroenterology 1979; 77:28A).
No reprints available.
- Issue published online: 21 SEP 2007
- Article first published online: 21 SEP 2007
- Manuscript Accepted: 18 AUG 1982
- Manuscript Received: 23 APR 1982
- Hastings Foundation, Los Angeles, California.
The effect of inhibitors of prostaglandin synthesis on diuretic action was examined in patients with ascites due to chronic liver disease and in normal subjects. In patients with ascites, natriuresis after 80 mg i.v. furosemide was reduced 82% by pretreatment with indomethacin. Creatinine clearance was reduced only 16%. These effects were likely due to inhibition of renal prostaglandin synthesis, since urinary prostaglandin E2 fell and there was also reduction in natriuresis with naproxen (52%). The effects were not specific for furosemide since spironolactone-induced natriuresis was also reduced by indomethacin (82%), naproxen (52%), and aspirin (33%). In normal subjects, indomethacin reduced furosemide natriuresis by only 14% while creatinine clearance was not affected. The mechanisms of these, drug interactions are uncertain but probably involve renal hemodynamics which appear to be supported importantly by renal prostaglandins in patients with ascites due to liver disease.