An Analysis of the Composition of the Inflammatory Infiltrate in Autoimmune and Hepatitis B Virus-Induced Chronic Liver Disease

Authors

  • Luis Montano,

    1. Departments of Medicine and Immunology, Royal Free Hospital, School of Medicine, Pond Street, Hampstead, London NW3 2QG, England
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  • Fernando Aranguibel,

    1. Departments of Medicine and Immunology, Royal Free Hospital, School of Medicine, Pond Street, Hampstead, London NW3 2QG, England
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  • Margarita Boffill,

    1. Departments of Medicine and Immunology, Royal Free Hospital, School of Medicine, Pond Street, Hampstead, London NW3 2QG, England
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  • Alison H. Goodall,

    1. Departments of Medicine and Immunology, Royal Free Hospital, School of Medicine, Pond Street, Hampstead, London NW3 2QG, England
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  • George Janossy,

    1. Departments of Medicine and Immunology, Royal Free Hospital, School of Medicine, Pond Street, Hampstead, London NW3 2QG, England
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  • Howard C. Thomas

    Corresponding author
    1. Departments of Medicine and Immunology, Royal Free Hospital, School of Medicine, Pond Street, Hampstead, London NW3 2QG, England
    • Howard C. Thomas, M.B., Ph.D., F.R.C.P., Department of Medicine, Royal Free Hospital and Medical School, Pond Street, Hampstead, London NW3 2QG, England.
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    • Dr. Thomas is a Senior Wellcome Fellow in Clinical Science


Abstract

The composition of the mononuclear cell infiltrate in the liver was studied in patients with autoimmune and hepatitis B virus (HBV)-induced liver disease. The ratio of inducer to cytotoxic/ suppressor cells was greater in patients with lupoid chronic active liver disease, primary biliary cirrhosis, and HBeAb positive HBV-induced chronic active liver disease than in patients with HBeAg positive HBV-induced chronic hepatitis. In patients with chronic HBV-induced (HBeAb positive) liver disease, this ratio was greater in the periportal/portal area than in the lobule. These data are consistent with a relative deficiency of the cytotoxic/suppressor population of T cells in autoimmune liver diseases and possibly in HBeAb positive HBV-induced chronic active liver disease. In the latter patients, different ratios in the periportal and centrilobular zones suggest different mechanisms for periportal and lobular hepatitis.

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