Cytoplasmic Tubular Structures in Liver of HBsAg Carrier Chimpanzees Infected with Delta Agent and Comparison with Cytoplasmic Structures in Non-A, Non-B Hepatitis

Authors

  • Tomoteru Kamimura,

    1. The Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Division of Molecular and Viral Immunology, Georgetown University Medical Center, Rockville, Maryland; The Third Division of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan; Ospedale S. Giovanni Battista di Torino, Dipartimento di Gastroenterologia, Torino, Italy
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  • Antonio Ponzetto,

    1. The Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Division of Molecular and Viral Immunology, Georgetown University Medical Center, Rockville, Maryland; The Third Division of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan; Ospedale S. Giovanni Battista di Torino, Dipartimento di Gastroenterologia, Torino, Italy
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  • Ferruccio Bonino,

    1. The Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Division of Molecular and Viral Immunology, Georgetown University Medical Center, Rockville, Maryland; The Third Division of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan; Ospedale S. Giovanni Battista di Torino, Dipartimento di Gastroenterologia, Torino, Italy
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  • Stephen M. Feinstone,

    1. The Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Division of Molecular and Viral Immunology, Georgetown University Medical Center, Rockville, Maryland; The Third Division of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan; Ospedale S. Giovanni Battista di Torino, Dipartimento di Gastroenterologia, Torino, Italy
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  • John L. Gerin,

    1. The Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Division of Molecular and Viral Immunology, Georgetown University Medical Center, Rockville, Maryland; The Third Division of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan; Ospedale S. Giovanni Battista di Torino, Dipartimento di Gastroenterologia, Torino, Italy
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  • Robert H. Purcell

    Corresponding author
    1. The Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Division of Molecular and Viral Immunology, Georgetown University Medical Center, Rockville, Maryland; The Third Division of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan; Ospedale S. Giovanni Battista di Torino, Dipartimento di Gastroenterologia, Torino, Italy
    • Robert H. Purcell, M.D., Building 7, Room 202, National Institutes of Health, Bethesda, Maryland 20205.
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Abstract

Electron microscopic observations were carried out on five HBsAg carrier chimpanzees infected with delta (δ) agent and two chimpanzees infected with human non-A, non-B hepatitis. The cytoplasmic tubular structures, which have been recognized in the liver of chimpanzees infected with human non-A, non-B hepatitis, were found also in the liver of HBsAg carrier chimpanzees infected with 5 agent. The quantity of the cytoplasmic structures in serial studies was associated with SGPT elevation rather than with expression of ± antigen in sera and liver tissues. This indicates that the cytoplasmic structures reflect a pathologic change of the hepatocytes in chimpanzees infected with ± agent or human non-A, non-B hepatitis. These and other similarities between the two agents suggest a similar nature.

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