Immunoregulatory T Cell Subsets in Chronic Hepatitis B Virus Infection: The Influence of Homosexuality
Article first published online: 21 SEP 2007
Copyright © 1983 American Association for the Study of Liver Diseases
Volume 3, Issue 6, pages 951–954, 1983
How to Cite
Regenstein, F. G., Roodman, S. T. and Perrillo, R. P. (1983), Immunoregulatory T Cell Subsets in Chronic Hepatitis B Virus Infection: The Influence of Homosexuality. Hepatology, 3: 951–954. doi: 10.1002/hep.1840030612
- Issue published online: 21 SEP 2007
- Article first published online: 21 SEP 2007
- Manuscript Accepted: 1 JUN 1983
- Manuscript Received: 8 FEB 1983
The purposes of this study were 2-fold: (i) To enumerate peripheral immunoregulatory T cell subsets in untreated patients with chronic hepatitis B virus (HBV) infection and (ii) to examine the relationship between disturbances in the balance of lymphocyte subsets with liver disease and the presence of homosexuality. Circulating T lymphocyte subsets were evaluated by monoclonal antibodies to the following cell antigens: OKT3 (total T cells), OKT4 (helper/inducer T cells), and 0KT8 (suppressor/cytotoxic T cells). The following groups of subjects were examined: (i) 16 heterosexuals with HBV-associated chronic active hepatitis (CAHB); (ii) 10 heterosexual, healthy HBsAg carriers, and (iii) 16 male homosexuals with CAHB. Controls included 51 healthy heterosexuals and 12 healthy, noninfected male homosexuals.
We were able to demonstrate that heterosexuals with CAHB had T4/T8 ratios which did not differ from those of noninfected heterosexuals. Both healthy carriers and healthy homosexuals, however, exhibited significantly lower T4/T8 ratios than did noninfected heterosexuals (p < 0.05, p < 0.01, respectively). In addition, homosexuals with CAHB had lower (1.5 ± 0.1) T4/T8 ratios than did heterosexuals with CAHB (2.0 ± 0.2).
A possible mechanism for these findings is discussed. The data indicate that the presence of homosexuality may be an important factor to consider when evaluating immunoregulatory subsets in CAHB.