A Randomized Controlled Study of Propranolol for Prevention of Recurrent Gastrointestinal Bleeding in Patients with Cirrhosis: A Final Report

Authors

  • Didier Lebrec,

    Corresponding author
    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
    • Dr. Didier Lebrec, INSERM U-24, Hopital Beaujon, 92118 Clichy, France.
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  • Thierry Poynard,

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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  • Jacques Bernuau,

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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  • Eric Bercoff,

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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  • Olivier Nouel,

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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  • Jean-Pierre Capron,

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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  • Raoul Poupon,

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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  • Michel Bouvry,

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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  • Bernard Rueff,

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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  • Jean-Pierre Benhamou

    1. Unité de Recherches de Physiopathologie Hépatlque (INSERM), Hopital Beaujon, Clichy, France; Centre Hospitaller Uniuersltaire d'Amiens, Amiens, France; Hǒpital Salnt-Antolne, Paris, France; and Centre Hospitaller de Pontolse, Pontolse, France
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Abstract

We have previously reported the results of a controlled trial showing that continuous oral administration of propranolol reduced the risk of recurrent gastrointestinal bleeding in patients with cirrhosis; only part of our patients had been followed for 1 year. This controlled trial was continued for an additional year; accordingly, all of our patients have now been followed for at least 2 years. The purpose of the present study is to determine whether prolonged administration enhances the efficacy of this therapy.

Seventy-four patients with cirrhosis, admitted for an episode of gastrointestinal bleeding, were included in this study; ascites, jaundice and encephalopathy were absent or mild and transient. The patients were randomly assigned to two groups; one group of 38 patients received propranolol twice daily at doses that reduced the resting heart rate by 25%, the other group of 36 patients received a placebo twice daily. The cumulative percentages of patients free of recurrent gastrointestinal bleeding 1 and 2 years after inclusion were 87 and 79% in the propranolol group, and 42 and 32% in the placebo group; both differences were highly significant (p < 0.0001). Furthermore, the cumulative percentages of surviving patients 1 and 2 years after inclusion were 94 and 90% in the propranolol group, and 84 and 57% in the placebo group; the difference between the two groups was not significant at 1 year, but was statistically significant at 2 years (p < 0.02). We conclude that, in patients with cirrhosis in good condition, propranolol reduced the risk of recurrent gastrointestinal bleeding and the mortality rate during the 2-year period of continuous oral administration of the drug.

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