A portion of this work was presented at the Seventy-First Annual Meeting of the International Academy of Pathology, Boston, Massachusetts, March 1, 1982, and is found in abstract form (Lab. Invest. 1982; 46:71A).
Article first published online: 24 JUL 2008
Copyright © 1984 American Association for the Study of Liver Diseases
Volume 4, Issue 4, pages 671–677, July-August 1984
How to Cite
Rubel, L. R., Rabin, L., Seeff, L. B., Licht, H. and Cuccherini, B. A. (1984), Does Primary Biliary Cirrhosis in Men Differ from Primary Biliary Cirrhosis in Women?. Hepatology, 4: 671–677. doi: 10.1002/hep.1840040418
The files of the Armed Forces Institute of Pathology include case material from military, Veterans Administration and civilian sources.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy, Veterans Administration, or the Department of Defense.
- Issue published online: 24 JUL 2008
- Article first published online: 24 JUL 2008
- Manuscript Accepted: 27 FEB 1984
- Manuscript Received: 7 MAY 1982
Primary biliary cirrhosis is infrequently diagnosed in men, so that the clinical, biochemical and histopathological spectrum of this disease in men has not been evaluated. Therefore, we studied 30 men who had a histological diagnosis of primary biliary cirrhosis and had positive tests for antimitochondrial antibodies. Five patients had no hepatobiliary symptoms, and two of these patients had neither biochemical nor histological evidence of cholestasis. These 30 male patients' findings were compared with the findings in 30 age-matched women who also had primary biliary cirrhosis and antimitochondrial antibodies. Six of these patients were asymptomatic. Clinical findings and symptomatic status, in addition to biochemical and histopathological features, were generally similar in both male and female patients. The possible significance of higher serum alkaline phosphatase activities and lower frequency of occurrence of piecemeal necrosis in men with primary biliary cirrhosis, as compared with women, requires further study.