Does Primary Biliary Cirrhosis in Men Differ from Primary Biliary Cirrhosis in Women?§

Authors

  • Lawrence R. Rubel,

    1. Armed Forces Institute of Pathology and The Veterans Administration Special Reference Laboratory for Pathology at the AFIP, Veterans Administration Medical Center, and Georgetown University School of Medicine, Washington, D.C. 20306
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  • Lionel Rabin,

    Corresponding author
    1. Armed Forces Institute of Pathology and The Veterans Administration Special Reference Laboratory for Pathology at the AFIP, Veterans Administration Medical Center, and Georgetown University School of Medicine, Washington, D.C. 20306
    • Lionel Rabin, M.D., Department of Hepatic Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306.
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  • Leonard B. Seeff,

    1. Armed Forces Institute of Pathology and The Veterans Administration Special Reference Laboratory for Pathology at the AFIP, Veterans Administration Medical Center, and Georgetown University School of Medicine, Washington, D.C. 20306
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  • Harvey Licht,

    1. Armed Forces Institute of Pathology and The Veterans Administration Special Reference Laboratory for Pathology at the AFIP, Veterans Administration Medical Center, and Georgetown University School of Medicine, Washington, D.C. 20306
    Current affiliation:
    1. Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104.
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  • Brenda A. Cuccherini

    1. Armed Forces Institute of Pathology and The Veterans Administration Special Reference Laboratory for Pathology at the AFIP, Veterans Administration Medical Center, and Georgetown University School of Medicine, Washington, D.C. 20306
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  • A portion of this work was presented at the Seventy-First Annual Meeting of the International Academy of Pathology, Boston, Massachusetts, March 1, 1982, and is found in abstract form (Lab. Invest. 1982; 46:71A).

  • The files of the Armed Forces Institute of Pathology include case material from military, Veterans Administration and civilian sources.

  • §

    The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy, Veterans Administration, or the Department of Defense.

Abstract

Primary biliary cirrhosis is infrequently diagnosed in men, so that the clinical, biochemical and histopathological spectrum of this disease in men has not been evaluated. Therefore, we studied 30 men who had a histological diagnosis of primary biliary cirrhosis and had positive tests for antimitochondrial antibodies. Five patients had no hepatobiliary symptoms, and two of these patients had neither biochemical nor histological evidence of cholestasis. These 30 male patients' findings were compared with the findings in 30 age-matched women who also had primary biliary cirrhosis and antimitochondrial antibodies. Six of these patients were asymptomatic. Clinical findings and symptomatic status, in addition to biochemical and histopathological features, were generally similar in both male and female patients. The possible significance of higher serum alkaline phosphatase activities and lower frequency of occurrence of piecemeal necrosis in men with primary biliary cirrhosis, as compared with women, requires further study.

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