Long-Term Sequelae of Non-A, Non-B Hepatitis in Experimentally Infected Chimpanzees

Authors

  • Kenneth H. Burk,

    Corresponding author
    1. Warner-Lambert Technologies, Inc., Nuclear-Medical Laboratories, Research and Development, Irving, Texas 75061; Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 77030; Department of Microbiology and Immunology, Medical College of Virginia, Richmond, Virginia 23298; and Department of Pathology, USC Liver Unit, University of Southern California School of Medicine, Rancho Los Amigos Hospital, Downey, California 90242
    Current affiliation:
    1. Virology and Immunology Department, Southwest Foundation for Biomedical Research, W. Loop 410 at Military Drive, San Antonio, Texas 78284
    • Kenneth H. Burk, Ph.D., Research and Development, Nuclear-Medical Laboratories, 1800 Hurd Drive, Irving, Texas 75061.
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  • Gordon R. Dreesman,

    1. Warner-Lambert Technologies, Inc., Nuclear-Medical Laboratories, Research and Development, Irving, Texas 75061; Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 77030; Department of Microbiology and Immunology, Medical College of Virginia, Richmond, Virginia 23298; and Department of Pathology, USC Liver Unit, University of Southern California School of Medicine, Rancho Los Amigos Hospital, Downey, California 90242
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  • Guy A. Cabral,

    1. Warner-Lambert Technologies, Inc., Nuclear-Medical Laboratories, Research and Development, Irving, Texas 75061; Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 77030; Department of Microbiology and Immunology, Medical College of Virginia, Richmond, Virginia 23298; and Department of Pathology, USC Liver Unit, University of Southern California School of Medicine, Rancho Los Amigos Hospital, Downey, California 90242
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  • Robert L. Peters

    1. Warner-Lambert Technologies, Inc., Nuclear-Medical Laboratories, Research and Development, Irving, Texas 75061; Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 77030; Department of Microbiology and Immunology, Medical College of Virginia, Richmond, Virginia 23298; and Department of Pathology, USC Liver Unit, University of Southern California School of Medicine, Rancho Los Amigos Hospital, Downey, California 90242
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Abstract

We have observed the development of long-term sequelae in four cases of experimentally induced non-A, non-B (NANB) hepatitis in chimpanzees. These sequelae were characterized by the following manifestations: nonprotection against challenge with autologous infectious plasma following acute disease and subtle histopathological alterations typical of long-lasting viral hepatitis. These manifestations were observed in animals infected with either of two human inocula. Whether or not these inocula represent sources of single or multiple etiologic agents is not known. However, our studies suggest that these inocula share at least one common etiologic agent. Further, these results may represent an atypical chronology of convalescence from viral hepatitis infection. For example, the convalescent stage of a type B hepatitis infection may be expected to occur within 6 to 8 months following exposure, whereas true convalescence in NANB hepatitis may be protracted over several months to several years. Thus, future efforts to identify the causative agent(s) of NANB hepatitis, and efforts to define the immune response in NANB, must take into consideration these studies.

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