Serum α-L-Fucosidase: A New Marker for the Diagnosis of Primary Hepatic Carcinoma?

Authors

  • Yves Deugnier,

    Corresponding author
    1. Laboratoire d' Anatomie et de Cytologie Pathologiques, Clinique des Maladies du Foie and INSERM U49, Laboratoire de Biochimie Medicate B, CHU Pontchaillou, 35011 Rennes Cedex, France
    • Dr. Y. Deugnier, Laboratoire d'Anatomie et de Cytologie Pathologiques, CHU Pontchallou, 35011 Rennes Cedex, France.
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  • Véronique David,

    1. Laboratoire d' Anatomie et de Cytologie Pathologiques, Clinique des Maladies du Foie and INSERM U49, Laboratoire de Biochimie Medicate B, CHU Pontchaillou, 35011 Rennes Cedex, France
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  • Pierre Brissot,

    1. Laboratoire d' Anatomie et de Cytologie Pathologiques, Clinique des Maladies du Foie and INSERM U49, Laboratoire de Biochimie Medicate B, CHU Pontchaillou, 35011 Rennes Cedex, France
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  • Philippe Mabo,

    1. Laboratoire d' Anatomie et de Cytologie Pathologiques, Clinique des Maladies du Foie and INSERM U49, Laboratoire de Biochimie Medicate B, CHU Pontchaillou, 35011 Rennes Cedex, France
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  • Damien Delamaire,

    1. Laboratoire d' Anatomie et de Cytologie Pathologiques, Clinique des Maladies du Foie and INSERM U49, Laboratoire de Biochimie Medicate B, CHU Pontchaillou, 35011 Rennes Cedex, France
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  • Michel Messner,

    1. Laboratoire d' Anatomie et de Cytologie Pathologiques, Clinique des Maladies du Foie and INSERM U49, Laboratoire de Biochimie Medicate B, CHU Pontchaillou, 35011 Rennes Cedex, France
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  • Michel Bourel,

    1. Laboratoire d' Anatomie et de Cytologie Pathologiques, Clinique des Maladies du Foie and INSERM U49, Laboratoire de Biochimie Medicate B, CHU Pontchaillou, 35011 Rennes Cedex, France
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  • Jean-Yves Legall

    1. Laboratoire d' Anatomie et de Cytologie Pathologiques, Clinique des Maladies du Foie and INSERM U49, Laboratoire de Biochimie Medicate B, CHU Pontchaillou, 35011 Rennes Cedex, France
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Abstract

α-L-fucosidase, a lysosomal enzyme which catabolizes fucoproteins, was studied in sera from 30 controls, 32 patients with primary hepatic carcinomas, 24 patients with secondary metastatic liver carcinomas and 36 patients with cirrhosis.

Serum α-L-fucosidase was increased in primary hepatic carcinomas (145.5 ± 12 nkat per liter) with a high statistical significance versus controls (51.4 ± 4.5 – p & 10−7), secondary metastatic liver carcinomas (58.9 ± 6.4 – p < 10−5) and cirrhotics (71.3 ± 6 – p < 10−5). A level exceeding 110 was a useful marker for the diagnosis of primary hepatic carcinoma with 75% sensitivity and 90% specificity.

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