Close Association Between Basal Cell Layer Antibodies and Hepatitis B Virus-Associated Chronic Delta Infection
Article first published online: 24 JUL 2008
Copyright © 1984 American Association for the Study of Liver Diseases
Volume 4, Issue 6, pages 1103–1106, November-December 1984
How to Cite
Zauli, D., Fusconi, M., Crespi, C., Bianchi, F. B., Craxi, A. and Pisi, E. (1984), Close Association Between Basal Cell Layer Antibodies and Hepatitis B Virus-Associated Chronic Delta Infection. Hepatology, 4: 1103–1106. doi: 10.1002/hep.1840040601
- Issue published online: 24 JUL 2008
- Article first published online: 24 JUL 2008
- Manuscript Accepted: 15 JUN 1984
- Manuscript Received: 7 MAR 1984
- C.N.R.. Grant Number: 822232
Antibodies reacting in immunofluorescence with the basal cell layer of rat forestomach (BCLA) have been detected in 36 of 121 (30%) hepatitis B virus (HBV)-mediated chronic liver disease (CLD), in 1 of 30 (3%) HBV-negative CLD, in 3 of 36 (8%) alcoholic liver disease (with no correlation with serum HBV markers), in 1 of 25 (4%) primary biliary cirrhosis, in none of 19 HBV-related HBsAg-negative CLD and 60 healthy blood donors. Of 352 hospitalized patients with miscellaneous diseases (including immunological conditions), the antibodies were found in four (1%).
In the 36 BCLA positive cases from HBV-mediated CLD, evidence of chronic delta infection was found in 34. The overall prevalence of BCLA in 68 delta cases was 50% (58% in chronic active hepatitis, 46% in cirrhosis), and in 28 delta negative cases was 4% (p < 0.00002).
BCLA of delta cases were mainly of the IgG class (38 of 41 sera), and high titers (up to 40,960) were found in the majority (66% >1:640).
The high titer BCLA has to be considered a marker of chronic delta infection in HBV cases.