Article

Immunohistochemical Distribution of Glucagon, Substance P and Vasoactive Intestinal Polypeptide in Hepatic Vasculature of the Rat

  1. Yutaka Sasaki*,
  2. Takenobu Kamada,
  3. Norio Hayashi,
  4. Nobuhiro Sato,
  5. Akinori Kasahara,
  6. Hideyuki Fusamoto,
  7. Sadao Shiosaka,
  8. Masaya Tohyama,
  9. Yahe Shiotani

Article first published online: 24 JUL 2008

DOI: 10.1002/hep.1840040614

Issue

Hepatology

Hepatology

Volume 4, Issue 6, pages 1184–1189, November-December 1984

Additional Information

How to Cite

Sasaki, Y., Kamada, T., Hayashi, N., Sato, N., Kasahara, A., Fusamoto, H., Shiosaka, S., Tohyama, M. and Shiotani, Y. (1984), Immunohistochemical Distribution of Glucagon, Substance P and Vasoactive Intestinal Polypeptide in Hepatic Vasculature of the Rat. Hepatology, 4: 1184–1189. doi: 10.1002/hep.1840040614

Author Information

  1. First Department of Internal Medicine and Department of Neuroanatomy, Institute of Higher Nervous Activity, Osaka University Medical School, 1–1–50, Fukushima, Fukushimaku, Osaka 553, Japan

*Yutaka Sasaki, M.D., First Department of Internal Medicine, Osaka University Medical School, 1–1–50, Fukushima, Fukushima-ku, Osaka 553, Japan.

Publication History

  1. Issue published online: 24 JUL 2008
  2. Article first published online: 24 JUL 2008
  3. Manuscript Accepted: 12 JUL 1984
  4. Manuscript Received: 17 OCT 1983

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Abstract

The distribution of immunoreactive glucagon, substance P (SP) and vasoactive intestinal polypeptide (VIP)-like structures was investigated in the rat liver, with special reference to the hepatic vasculature by means of the indirect immunofluorescence method. Immunoreactive structures of glucagon were seen in the walls of the portal vein, hepatic artery and hepatic vein, but not in the central vein. Immunoreactive glucagon was localized in the smooth muscle cells of these blood vessels. SP and VIP-like immunoreactive (SPI and VIPI) structures were seen in the neuronal elements. In the porta hepatis, thick, compact SPI and VIPI fibers, which were dissociated from their fiber bundles, reached the tunica adventitia where they were distributed. No SPI and VIPI structures were seen in the tunica media or the tunica interna. No SPI- and VIPI-containing cell bodies could be detected in the liver. These observations suggest that these peptides may have an important role in the neural regulation of hepatic hemodynamics.

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