Orthotopic Liver Transplantation in Groningen, The Netherlands (1979–1983)

Authors

  • Ruud A. F. Krom,

    Corresponding author
    1. Departments of Surgery, Internal Medicine, Pathological Anatomy, Anesthesia, Medical Microbiology, and the Blood Grouping Laboratory of the University Hospital Groningen, Groningen, The Netherlands
    • Ruud A. F. Krom, M.D., University Hospital Groningen, Department of Surgery, Oostersingel 59, 9713 EZ Groningen, The Netherlands.
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  • Chris H. Gips,

    1. Departments of Surgery, Internal Medicine, Pathological Anatomy, Anesthesia, Medical Microbiology, and the Blood Grouping Laboratory of the University Hospital Groningen, Groningen, The Netherlands
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  • Hendrik J. Houthoff,

    1. Departments of Surgery, Internal Medicine, Pathological Anatomy, Anesthesia, Medical Microbiology, and the Blood Grouping Laboratory of the University Hospital Groningen, Groningen, The Netherlands
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  • Douglas Newton,

    1. Departments of Surgery, Internal Medicine, Pathological Anatomy, Anesthesia, Medical Microbiology, and the Blood Grouping Laboratory of the University Hospital Groningen, Groningen, The Netherlands
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  • Dirk V. D. Waaij,

    1. Departments of Surgery, Internal Medicine, Pathological Anatomy, Anesthesia, Medical Microbiology, and the Blood Grouping Laboratory of the University Hospital Groningen, Groningen, The Netherlands
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  • José Beelen,

    1. Departments of Surgery, Internal Medicine, Pathological Anatomy, Anesthesia, Medical Microbiology, and the Blood Grouping Laboratory of the University Hospital Groningen, Groningen, The Netherlands
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  • Elizabeth B. Haagsma,

    1. Departments of Surgery, Internal Medicine, Pathological Anatomy, Anesthesia, Medical Microbiology, and the Blood Grouping Laboratory of the University Hospital Groningen, Groningen, The Netherlands
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  • Maarten J. H. Slooff

    1. Departments of Surgery, Internal Medicine, Pathological Anatomy, Anesthesia, Medical Microbiology, and the Blood Grouping Laboratory of the University Hospital Groningen, Groningen, The Netherlands
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Abstract

From March, 1979 to March, 1983, 26 orthotopic liver transplantations and 1 retransplantation were performed in our center. Sixteen patients are alive, 5 beyond22 years and 1 longer than 4 years after transplantation. The actuarial 1– and 2–year survival is 60%. Factors contributing to this result are patient selection and biliary anastomosis. In cirrhotic patients, the degree of deterioration of liver function correlated with survival; in patients with hepatocellular carcinoma, extrahepatic spread of tumor was the most frequent limiting factor. Choledochocholedochostomy with a widening plasty had a low complication rate providing that the arterial blood supply was undisturbed. Until now, HLA-matching has not contributed to the result of liver transplantation, although the effect for long-term survival is still unknown. The high survival rate and excellent quality of life of long-term survivors justify liver transplantation as treatment for otherwise noncurable liver diseases.

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