Ultrastructural evidence for the presence of ferritin-iron in the biliary system of patients with iron overload
Article first published online: 6 DEC 2005
Copyright © 1986 American Association for the Study of Liver Diseases
Volume 6, Issue 1, pages 30–35, January/February 1986
How to Cite
Cleton, M. I., Sindram, J. W., Rademakers, L. H. P. M., Zuyderhoudt, F. M. J., De Bruijn, W. C. and Marx, J. J. M. (1986), Ultrastructural evidence for the presence of ferritin-iron in the biliary system of patients with iron overload. Hepatology, 6: 30–35. doi: 10.1002/hep.1840060107
- Issue published online: 6 DEC 2005
- Article first published online: 6 DEC 2005
- Manuscript Accepted: 12 AUG 1985
- Manuscript Received: 4 MAR 1985
Ferritin-like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and phosphorus.
Morphological observation of coated vesicles in the cytoplasm adjacent to the bile canaliculi and coated pits in the canalicular membrane suggests a transport mechanism via membrane-bound organelles.
Support is given to the theory that part of the iron, stored in the liver, leaves the hepatocyte by excretion of ferritininto the bile.