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Original Article
The prognosis of chronic active hepatitis without cirrhosis in relation to bridging necrosis
Article first published online: 6 DEC 2005
DOI: 10.1002/hep.1840060302
Copyright © 1986 American Association for the Study of Liver Diseases
1527-3350/asset/cover.gif?v=1&s=3cd983af6575c8dbfd6b47a63ffa95415ace15f8 "Hepatology")
Additional Information
How to Cite
Graham, W., Cooksley, E., Bradbear, R. A., Robinson, W., Harrison, M., Halliday, J. W., Powell, L. W., Ng, H.-S., Seah, C.-S., Okuda, K., Scheuer, P. J. and Sherlock, S. (1986), The prognosis of chronic active hepatitis without cirrhosis in relation to bridging necrosis. Hepatology, 6: 345–348. doi: 10.1002/hep.1840060302
Publication History
- Issue published online: 6 DEC 2005
- Article first published online: 6 DEC 2005
- Manuscript Accepted: 20 SEP 1985
- Manuscript Received: 28 NOV 1984
Funded by
- Wellcome Foundation
- Clive and Vera Ramaciotti Medical Research Foundations
- National Health and Medical Research Council of Australia
- Abstract
- References
- Cited By
Abstract
Sixty-nine patients with chronic active hepatitis without cirrhosis were studied to define the prognostic implications of bridging necrosis of various types. There were 19 patients without bridging necrosis compared with 50 patients with bridging necrosis. The two groups did not differ significantly at presentation in age, sex, clinical or laboratory features. In the group without bridging necrosis, no patient died from the disease and none of 13 having a later biopsy developed cirrhosis. In the group with bridging necrosis, one patient died from hepatic failure and 7 of 36 developed cirrhosis (19%). When analyzed statistically, a significant (p<0.05) relationship is seen between increasing severity of initial lesion and the subsequent development of cirrhosis. It is concluded that patients with piecemeal necrosis without bridging should not be grouped together with patients with bridging necrosis or cirrhosis when considering management decisions.