Prevention of maternal-infant hepatitis B virus transmission by immunization: The role of serum hepatitis B virus DNA

Authors

  • Shou-Dong Lee M.D.,

    Corresponding author
    1. Division of Gastroenterology, Department of Medicine, Veterans General Hospital, and Graduate Program of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China; and The Liver Center, Huntington Memorial Hospital, Pasadena, California 91105
    • Division of Gastroenterology, Veterans General Hospital, Taipei, Taiwan 112, Republic of China
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  • Kwang-Juei Lo,

    1. Division of Gastroenterology, Department of Medicine, Veterans General Hospital, and Graduate Program of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China; and The Liver Center, Huntington Memorial Hospital, Pasadena, California 91105
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  • Jaw-Ching Wu,

    1. Division of Gastroenterology, Department of Medicine, Veterans General Hospital, and Graduate Program of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China; and The Liver Center, Huntington Memorial Hospital, Pasadena, California 91105
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  • Yang-Te Tsai,

    1. Division of Gastroenterology, Department of Medicine, Veterans General Hospital, and Graduate Program of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China; and The Liver Center, Huntington Memorial Hospital, Pasadena, California 91105
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  • Jiin-Yu Wang,

    1. Division of Gastroenterology, Department of Medicine, Veterans General Hospital, and Graduate Program of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China; and The Liver Center, Huntington Memorial Hospital, Pasadena, California 91105
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  • Ling-Pai Ting,

    1. Division of Gastroenterology, Department of Medicine, Veterans General Hospital, and Graduate Program of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China; and The Liver Center, Huntington Memorial Hospital, Pasadena, California 91105
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  • Myron J. Tong

    1. Division of Gastroenterology, Department of Medicine, Veterans General Hospital, and Graduate Program of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China; and The Liver Center, Huntington Memorial Hospital, Pasadena, California 91105
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Abstract

Sera from 108 HBsAg carrier mothers at delivery and their respective offspring at birth and at 6 months of age were examined for hepatitis B virus DNA by the dot-blot hybridization technique. Hepatitis B virus DNA was detected in 83% of 88 carrier mothers who were HBeAg positive, and in 10% of 20 carrier mothers who were HBeAg negative. All five infants born to HBeAg-positive carrier mothers with hepatitis B virus DNA levels over 80 pg per 10 μl of serum were infected by hepatitis B virus, in spite of receiving hepatitis B immunization. All 17 infants without hepatitis B immunization who were born to HBeAg and hepatitis B virus DNA-positive carrier mothers developed hepatitis B virus infection. Of 56 infants born to HBeAg and hepatitis B virus DNA-positive carrier mothers and who had received hepatitis B immunization, a higher hepatitis B virus infection rate was found in a group of infants whose sera hepatitis B virus DNA were positive (15/16, 93.8%) than in infants whose sera were negative (17/40, 42.5%) at birth (p<0.0005). These data suggest that the assay for hepatitis B virus DNA in sera of HBsAg carrier mothers at delivery or their infants at birth will predict the efficacy of hepatitis B immunization for prevention of maternal-infant hepatitis B virus transmission.

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