Natural course of delta superinfection in chronic hepatitis B virus-infected patients: Histopathologic study with multiple liver biopsies

Authors

  • Sugantha Govindarajan M.D.,

    Corresponding author
    1. Department of Pathology, University of Southern California, Liver Unit, Rancho Los Amigos Medical Center, Downey, California 90242
    • Department of Pathology, Rancho Los Amigos Medical Center, 7705 Golondrinas, Building 1200, Downey, California 90242
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  • Kevin M. de Cock,

    1. Department of Pathology, University of Southern California, Liver Unit, Rancho Los Amigos Medical Center, Downey, California 90242
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  • Allan G. Redeker

    1. Department of Pathology, University of Southern California, Liver Unit, Rancho Los Amigos Medical Center, Downey, California 90242
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Abstract

We evaluated the natural course of delta superinfection in patients with chronic B viral hepatitis by examining serial liver biopsy specimens from 23 patients. The mean follow-up period was 2.5 years, and the average number of liver biopsies per patient was 2.8. The striking features were: (i) the prolonged acute hepatitis-like necroinflammatory activity (mean = 15 months) following acute delta hepatitis and (ii) rapid progression to severe forms of liver disease within a mean interval of 24 months from the onset of delta superinfection. Although there was a high frequency of stainable delta antigen (90%) in these liver biopsy specimens, there was no correlation between the degree of positivity and the histopathological changes.

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