Peripheral T-cell lymphoma presenting as predominant liver disease: A report of three cases

Authors

  • Philippe Gaulard,

    1. Departement de Pathologie Tissulaire et Cellulaire, Service d'Hématologie and Unités de Recherches, INSERM U 99 and U 91, Hôpital Henri Mondor, 94010 Créteil, France
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  • Dr. Elie Serge Zafrani,

    Corresponding author
    1. Departement de Pathologie Tissulaire et Cellulaire, Service d'Hématologie and Unités de Recherches, INSERM U 99 and U 91, Hôpital Henri Mondor, 94010 Créteil, France
    • Département de Pathologie Tissulaire et Cellulaire, Service d'Anatomie et de Cytologie Pathologiques, Hôpital Henri Mondor, 94010 Creteil Cedex. France
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  • Philippe Mavier,

    1. Departement de Pathologie Tissulaire et Cellulaire, Service d'Hématologie and Unités de Recherches, INSERM U 99 and U 91, Hôpital Henri Mondor, 94010 Créteil, France
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  • Francisco Dario Rocha,

    1. Departement de Pathologie Tissulaire et Cellulaire, Service d'Hématologie and Unités de Recherches, INSERM U 99 and U 91, Hôpital Henri Mondor, 94010 Créteil, France
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  • Jean-Pierre Farcet,

    1. Departement de Pathologie Tissulaire et Cellulaire, Service d'Hématologie and Unités de Recherches, INSERM U 99 and U 91, Hôpital Henri Mondor, 94010 Créteil, France
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  • Marine Divine,

    1. Departement de Pathologie Tissulaire et Cellulaire, Service d'Hématologie and Unités de Recherches, INSERM U 99 and U 91, Hôpital Henri Mondor, 94010 Créteil, France
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  • Corinne Haioun,

    1. Departement de Pathologie Tissulaire et Cellulaire, Service d'Hématologie and Unités de Recherches, INSERM U 99 and U 91, Hôpital Henri Mondor, 94010 Créteil, France
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  • Yvon Pinaudeau

    1. Departement de Pathologie Tissulaire et Cellulaire, Service d'Hématologie and Unités de Recherches, INSERM U 99 and U 91, Hôpital Henri Mondor, 94010 Créteil, France
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Abstract

Three cases of a peculiar form of peripheral T-cell lymphoma presenting as predominant hepatic disease with splenomegaly are reported. The three patients had marked liver enlargement without lymphadenopathy; white blood cell count was normal, and modifications of hepatic tests were mild. In the three cases, the diagnosis of the lymphoma was mainly based on the results of hepatic morphological changes. Liver involvement was histologically characterized by a predominantly sinusoidal infiltration by tumor cells in the three cases, associated with perisinusoidal fibrosis in two of them; portal infiltration was noted in two patients. Immunopathological study showed that tumor cells were T-lymphoid cells that were different from normal T-lymphocytes by the lack of expression of one T-cell membrane antigen, i.e., Leu-1. These findings suggest that a distinct clinical, pathological and immunopathological entity might be individualized within the large group of T-cell lymphomas.

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