Cerebral CT scan abnormalities in cholestatic and hepatocellular disease and their relationship to neuropsychologic test performance

Authors

  • Patricia Bernthal,

    1. Departments of Psychiatry, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
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  • Amy Hays,

    1. Departments of Psychiatry, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
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  • Ralph E. Tarter Ph.D.,

    Corresponding author
    1. Departments of Psychiatry, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
    • Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15213
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  • David Van Thiel,

    1. Departments of Psychiatry, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
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  • James Lecky,

    1. Departments of Psychiatry, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
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  • Andrea Hegedus

    1. Departments of Psychiatry, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213
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Abstract

Forty-nine nonalcoholic cirrhotic patients, on whom cranial CT scans were available, were administered a battery of neuropsychological tests. Although none of the subjects exhibited clinical signs or symptoms of hepatic encephalopathy, quantification of the CT scan image implicated cerebral edema and cortical atrophy. In addition numerous significant correlations were observed between the CT variables and neuropsychological test performance. The findings are conjectured to reflect previously unrecognized cerebral morphologic changes associated with chronic subclinical portal-systemic encephalopathy.

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