Evidence that host size determines liver size: Studies in dogs receiving orthotopic liver transplants

Authors

  • Igal Kam,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Steven Lynch,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Gregory Svanas,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Satori Todo,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Lorenzo Polimeno,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Antonio Francavilla,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Ronald J. Penkrot,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Sunichi Takaya,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Bo G. Ericzon,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • Thomas E. Starzl,

    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • David H. Van Thiel M.D.

    Corresponding author
    1. Departments of Surgery, Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
    • 1000J Scaife Hall, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261
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Abstract

Orthotopic liver transplantation was performed in two groups of dogs; Group I animals consisted of large dogs that served as recipients of livers obtained from smaller dogs while Group II animals consisted of dogs that received liver from donor dogs of nearly the same size. The small-for-size livers transplanted into the Group I dogs rapidly increased in size over the course of 2 weeks until they achieved a size equal to that originally present in the larger recipient dogs. In contrast, the livers transplanted into dogs of the same size as the donors underwent some degree of atrophy. In both groups of animals, plasma levels of insulin and glucagon and hepatic (graft) activities of thymidine kinase and ornithine decarboxylase were followed serially. The only difference between the two groups of animals for these measures was that the ornithine decarboxylase activity rose to a greater degree in the liver that underwent graft enlargement. These data suggest that recipient size determines, at least in part, liver graft size once it is transplanted. These data also suggest that of the parameters followed, only ornithine decarboxylase activity parallels the finding of growth of the transplanted liver.

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