IgM anti-HBc in anti-HBe positive chronic type B hepatitis with acute exacerbations

Authors

  • Kazuhiko Koike,

    1. First Department of Internal Medicine, Faculty of Medicine and Department of Infectious Disease, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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  • Shiro Iino M.D.,

    Corresponding author
    1. First Department of Internal Medicine, Faculty of Medicine and Department of Infectious Disease, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    • First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan
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  • Kiyohiko Kurai,

    1. First Department of Internal Medicine, Faculty of Medicine and Department of Infectious Disease, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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  • Keiji Mitamura,

    1. First Department of Internal Medicine, Faculty of Medicine and Department of Infectious Disease, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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  • Yasuo Endo,

    1. First Department of Internal Medicine, Faculty of Medicine and Department of Infectious Disease, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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  • Hiroshi Oka

    1. First Department of Internal Medicine, Faculty of Medicine and Department of Infectious Disease, Institute of Medical Science, University of Tokyo, Tokyo, Japan
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Abstract

IgM anti-HBc was measured by radioimmunoassay in serially collected serum samples during 20 acute exacerbations which developed in 14 patients with anti-HBe positive chronic type B hepatitis. IgM anti-HBc became positive in 12 of the 14 (86%) patients and in 18 of the 20 (90%) exacerbations, and elevation of IgM anti-HBc which was believed to be significant was also observed in the remaining two patients. In most of the patients who also had determinations of serum hepatitis B virus DNA, the hepatitis B virus DNA became positive. These results suggest that ALT elevation in anti-HBe positive chronic type B hepatitis is associated with active replication of hepatitis B virus. It is considered to be useful to measure IgM anti-HBc for the purpose of identifying the causes of ALT elevation in anti-HBe positive chronic type B hepatitis.

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