S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis

Authors

  • Antonio Martín Duce,

    1. Metabolismo, Nutrición y Hormonas, Fundación Jiménez Díaz and Instituto de Biomedicina del CSIC, 28040 Madrid, Spain
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  • Pablo Ortíz,

    1. Metabolismo, Nutrición y Hormonas, Fundación Jiménez Díaz and Instituto de Biomedicina del CSIC, 28040 Madrid, Spain
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  • Carmen Cabrero,

    1. Metabolismo, Nutrición y Hormonas, Fundación Jiménez Díaz and Instituto de Biomedicina del CSIC, 28040 Madrid, Spain
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  • Dr. José M. Mato

    Corresponding author
    1. Metabolismo, Nutrición y Hormonas, Fundación Jiménez Díaz and Instituto de Biomedicina del CSIC, 28040 Madrid, Spain
    • Metabolismo, Nutricion y Hormonas, Fundacion Jimenez Diaz and Instituto de Biomedicina del CSIC, Avda. Reyes Catolicos, 2, 28040 Madrid, Spain
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Abstract

We have measured the activity S-adenosyl-L-methio-nine synthetase in liver biopsies from a group of controls (n = 17) and in 26 cirrhotics (12 alcoholic and 14 posthepatitic). The activity of this enzyme was markedly reduced in the group of cirrhotics (285 ± 32 pmoles per min per mg protein) when compared with that observed in controls (505 ± 37 pmoles per min per mg protein). No differences in S-adenosyl-L-methionine synthetase was observed between both groups of cirrhotics. Similarly, a marked reduction in the activity phospholipid methyltransferase was also observed in liver biopsies from the same group of cirrhotics (105 ± 12 pmoles per min per mg protein) when compared with the control subjects (241 ± 13 pmoles per min per mg protein). Again, no difference in the activity of this enzyme was observed between both groups of cirrhotics. These results indicated a marked deficiency in the metabolism of S-adenosyl-L-methionine in cirrhosis.

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