Expression of class I and class II major histocompatibility complex antigens on human hepatocytes

Authors

  • Alessandra Franco,

    1. Istituto I Clinica Medica, Universitá “La Sapienza” and Istituto Tumori “Regina Elena,” 00161 Rome, Italy
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  • Vincenzo Barnaba M.D.,

    Corresponding author
    1. Istituto I Clinica Medica, Universitá “La Sapienza” and Istituto Tumori “Regina Elena,” 00161 Rome, Italy
    • Associate Professor, Istituto I Clinica Medica, Policlinico Umberto I, 00161 Rome, Italy
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  • Piergiorgio Natali,

    1. Istituto I Clinica Medica, Universitá “La Sapienza” and Istituto Tumori “Regina Elena,” 00161 Rome, Italy
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  • Clara Balsano,

    1. Istituto I Clinica Medica, Universitá “La Sapienza” and Istituto Tumori “Regina Elena,” 00161 Rome, Italy
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  • Antonino Musca,

    1. Istituto I Clinica Medica, Universitá “La Sapienza” and Istituto Tumori “Regina Elena,” 00161 Rome, Italy
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  • Francesco Balsano

    1. Istituto I Clinica Medica, Universitá “La Sapienza” and Istituto Tumori “Regina Elena,” 00161 Rome, Italy
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Abstract

We analyzed whether normal human hepatocytes, which normally do not display Class II major histocompatibility complex antigens, can be induced to express them in vitro, and whether this induction has an in vivo counterpart in chronic liver diseases. While both α- and γ-interferon induced expression of Class I antigens, only γ-interferon induced expression of Class II antigens on hepatocytes in vitro. Recombinant interleukin 2 had no effect on major histocompatibility complex antigen expression. Both Class I and Class II antigens could be detected by indirect immunofluorescence on hepatocytes from patients with various forms of chronic liver disease, regardless of etiology. These findings suggest that γ-interferon produced by T lymphocytes that infiltrate the liver during the course of chronic hepatitis induces Class II major histocompatibility complex antigen expression and may endow the hepatocytes with the capacity to perform accessory (antigen-presenting) cell functions.

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