Histocompatibility antigens: Markers of susceptibility to and protection from alcoholic liver disease in a portuguese population

Authors

  • Estela Monteiro M.D., Ph.D.,

    Corresponding author
    1. Department of Medicine 2, Gastro Center (INIC) and Department of Pathology, Santa Maria University Hospital, Lisbon 1600, Portugal and Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
    • Professor of Gastroenterology, Department of Medicine 2—Gastro Unit (INIC), Santa Maria University Hospital, 1600 Lisbon, Portugal or Judith S. Gavaler, Ph.D., Associate Research Professor of Medicine, 1000G Scaife Hall, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
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  • M. Patricia Alves,

    1. Department of Medicine 2, Gastro Center (INIC) and Department of Pathology, Santa Maria University Hospital, Lisbon 1600, Portugal and Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • M. Livia Santos,

    1. Department of Medicine 2, Gastro Center (INIC) and Department of Pathology, Santa Maria University Hospital, Lisbon 1600, Portugal and Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Isabel Quintas,

    1. Department of Medicine 2, Gastro Center (INIC) and Department of Pathology, Santa Maria University Hospital, Lisbon 1600, Portugal and Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Amelia Baptista,

    1. Department of Medicine 2, Gastro Center (INIC) and Department of Pathology, Santa Maria University Hospital, Lisbon 1600, Portugal and Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Alberto Galvao-Teles,

    1. Department of Medicine 2, Gastro Center (INIC) and Department of Pathology, Santa Maria University Hospital, Lisbon 1600, Portugal and Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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  • Judith S. Gavaler

    1. Department of Medicine 2, Gastro Center (INIC) and Department of Pathology, Santa Maria University Hospital, Lisbon 1600, Portugal and Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
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Abstract

The distribution of six HLA antigens in a population of 88 Portuguese chronic alcohol abusers with biopsy-proven liver disease was compared to that in 66 Portuguese normal controls. Among the group of 88 alcohol abusers, the presence of HLA antigens A1, A9, A28 and Bw35 marked a significant 2.5- to 3-fold increased estimated risk for the development of alcohol-induced cirrhosis, while the presence of HLA B5 was found to be associated with a significantly decreased risk of alcohol-induced cirrhosis. Further, compared to controls, the estimated risk of any stage of alcohol-induced liver disease was significantly increased in alcoholic individuals with HLA A28 and Bw35, and the protective effect of HLA B5 was again observed. The findings of this study suggest that at least in a relatively homogeneous population group such as the Portuguese, the presence of HLA B5 may confer protection against alcohol-induced liver disease, including cirrhosis. The presence of HLA Bw35 and A28 appear to mark susceptibility to all histologic manifestations of alcohol-induced liver disease, while in addition to Bw35 and A28, A1 and A9 may mark increased risk for cirrhosis in particular.

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