Identification of biliprotein as a liver growth factor

Authors

  • Juan J. Díaz-Gil Ph.D.,

    Corresponding author
    1. Departments of Experimental Biochemistry and Gastroenterology, Clínica Puerta de Hierro, 28035 Madrid, Spain
    • Servicio de Bioquímica Experimental, Clínica Puerta de Hierro, San Martín de Porres, 4, 28035 Madrid, Spain
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  • Gonzalo Sánchez,

    1. Departments of Experimental Biochemistry and Gastroenterology, Clínica Puerta de Hierro, 28035 Madrid, Spain
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  • Carolina Trilla,

    1. Departments of Experimental Biochemistry and Gastroenterology, Clínica Puerta de Hierro, 28035 Madrid, Spain
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  • Pedro Escartín

    1. Departments of Experimental Biochemistry and Gastroenterology, Clínica Puerta de Hierro, 28035 Madrid, Spain
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Abstract

We determined the concentration of biliprotein in plasma of rats at different times after partial hepatectomy. From the same plasma samples, we purified a liver growth factor previously characterized by our group. When we plotted the 14 points studied, a linear relationship was obtained (r = 0.999; p < 0.001). This result, in addition to our group's recent identification of this liver growth factor as an albumin-bilirubin complex, strongly suggests that biliprotein is a liver growth factor.

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