Cocaine-induced hepatotoxicity

Authors

  • John M. Porter M.D.,

    1. The Johns Hopkins Medical Institutes, Baltimore, Maryland 21205 and Duke University Medical Center, Durham, North Carolina 27710
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  • Marc S. Sussman M.D.,

    1. The Johns Hopkins Medical Institutes, Baltimore, Maryland 21205 and Duke University Medical Center, Durham, North Carolina 27710
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  • Gerald M. Rosen Ph.D.

    1. The Johns Hopkins Medical Institutes, Baltimore, Maryland 21205 and Duke University Medical Center, Durham, North Carolina 27710
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Abstract

A patient with hepatonecrosis associated with cocaine use is presented. Postmortem examination of the liver showed marked periportal inflammation and necrosis, and mild diffuse fatty infiltration. These pathologic findings are identical to those previously reported in a mouse model of cocaine hepatotoxicity.

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