Changes in liver and spleen volume in alcoholic liver fibrosis of man

Authors

  • Kazuo Tarao M.D.,

    Corresponding author
    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
    • Department of Gastroenterology, Kanagawa Cancer Center Hospital, 54-2 Nakao-cho, Asahi-ku, Yokohama, 241, Japan
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  • Hiroshi Hoshino,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Ikuko Motohashi,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Kazuto Iimori,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Setsuo Tamai,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Yoshihiko Ito,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Seiichi Takagi,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Yubo Oikawa,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Shiro Unayama,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Takuya Fujiwara,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Kunio Odagiri,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Toshio Ikeda,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Kazuhiro Hayashi,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Akira Sakurai,

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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  • Toshiyuki Uchikoshi

    1. Department of Gastroenterology and Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan
    2. Department of Medicine, Kawasaki Kyodo Hospital, Kawasaki, Japan
    3. First Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan
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Abstract

Alcoholic liver fibrosis is a relatively common form of alcoholic liver disease in Japan. It is regarded by some investigators as a prodromal stage of alcoholic liver cirrhosis, but little is known about the volumes of the liver and spleen in this disease state. Therefore, liver and spleen volumes were measured by computed tomography in 32 patients with alcoholic liver fibrosis in comparison with 10 healthy volunteers. Patients with alcoholic liver fibrosis were divided into three subgroups (13 of Grade 1, 9 of Grade 2 and 10 of Grade 3) according to the severity of fibrosis. The volume was calculated from the sum of the area measurements of successive transverse sections of the two organs. The liver volume (mean ± S.D.) in Grade 2 alcoholic liver fibrosis (1,281 ± 112 cm3) was significantly (p < 0.01) larger than in healthy volunteers (1,017 ± 73 cm3) and in Grade 1 (1,090 ± 157 cm3), and the liver volume in Grade 3 (1,490 ± 132 cm3) was larger than in Grade 2 (p < 0.01). The mean volume of hepatocytes estimated by a two-dimensional image analysis system was significantly (p < 0.05) larger in Grade 3 than in Grade 2, and that in Grade 2 was larger than in Grade 1. The spleen volume in Grade 3 (151 ± 40 cm3) was significantly (p < 0.01) larger than in healthy volunteers (86 ± 26 cm3), Grade 1 (89 ± 38 cm3) and Grade 2 (68 ± 19 cm3). The presumed reason for hepatic volume increase would be the ballooning of hepatocytes along with increased fibrotic component.

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