Elevation of facilitated glucose-transporter messenger RNA in human hepatocellular carcinoma

Authors

  • Tsung-Sheng Su,

    Corresponding author
    1. Department of Medical Research, Veterans General Hospital, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
    2. Department of Genetics, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
    3. Department of Genetics, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
    • Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, Republic of China
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  • Ting-Fen Tsai,

    1. Department of Medical Research, Veterans General Hospital, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
    2. Department of Graduate Institutes of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
    3. Department of Graduate Institutes of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
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  • Chin-Wen Chi,

    1. Department of Medical Research, Veterans General Hospital, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
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  • Shou-Hwa Han,

    1. Department of Medical Research, Veterans General Hospital, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
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  • Chen-Kung Chou

    1. Department of Medical Research, Veterans General Hospital, National Yang-Ming Medical College, Taipei, Taiwan 11217 Republic of China
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Abstract

Complementary DNA of a rat brain glucose transporter gene was used to examine the expression of glucose-transporter messenger RNA in paired human hepatocellular carcinomas and adjacent nontumorous liver tissues, as well as in human hepatoma cell lines and human fetal liver samples. High expression of a major 2.8-kilobase glucose-transporter transcript was seen in all hepatoma cell lines and fetal liver samples examined, whereas a much lower level of expression was observed in liver tissues. When pairs of liver tissues were examined, elevation of glucose-transporter RNA levels was observed in most of the hepatocellular carcinoma tissues examined.

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