Pathogenesis of hepatocellular carcinoma in hereditary hemochromatosis: Occurrence in noncirrhotic patients



Previous reports have emphasized the association of primary hepatocellular carcinoma in patients with idiopathic hemochromatosis with cirrhosis. In contrast, patients with idiopathic hemochromatosis without cirrhosis have no increased risk of hepatocellular carcinoma. Phlebotomy therapy, by preventing the accumulation of parenchymal iron and subsequent cirrhosis, is believed to prevent hepatocellular carcinoma in the precirrhotic stage of the disease. We report the case of a 67-yr-old man with a 32-yr history of idiopathic hemochromatosis compliacated by cirrhosis, who had reversal of cirrhosis with phlebotomy theray, yet developed hepatocellular carcinoma. There was no serologic or tissue evidence of hepatitis B infection.